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2bpz

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[[Image:2bpz.jpg|left|200px]]
[[Image:2bpz.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2bpz |SIZE=350|CAPTION= <scene name='initialview01'>2bpz</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2bpz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=3IN:N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE'>3IN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.13.16 3.4.13.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HIV-1 PROTEASE FROM THE NY5 ISOLATE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_2bpz| PDB=2bpz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpz OCA], [http://www.ebi.ac.uk/pdbsum/2bpz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bpz RCSB]</span>
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}}
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'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''
'''HIV-1 PROTEASE-INHIBITOR COMPLEX'''
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[[Category: Chen, Z.]]
[[Category: Chen, Z.]]
[[Category: Munshi, S.]]
[[Category: Munshi, S.]]
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[[Category: acid protease]]
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[[Category: Acid protease]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:38:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:00 2008''
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Revision as of 17:38, 3 May 2008

Image:2bpz.jpg

Template:STRUCTURE 2bpz

HIV-1 PROTEASE-INHIBITOR COMPLEX


Overview

The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affords a fast turnaround of structural information for iterative rational drug designs and obviates the need for studying the complex structures by co-crystallization. The replacement approach has been successfully used with single crystals of the HIV-1 protease complexed with a weak inhibitor. The structures of the complexes obtained by the replacement method are similar to those determined by co-crystallization.

About this Structure

2BPZ is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme., Munshi S, Chen Z, Li Y, Olsen DB, Fraley ME, Hungate RW, Kuo LC, Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1053-60. PMID:9757136 Page seeded by OCA on Sat May 3 20:38:00 2008

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OCA

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