2bq1

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[[Image:2bq1.gif|left|200px]]
[[Image:2bq1.gif|left|200px]]
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{{Structure
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|PDB= 2bq1 |SIZE=350|CAPTION= <scene name='initialview01'>2bq1</scene>, resolution 3.99&Aring;
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The line below this paragraph, containing "STRUCTURE_2bq1", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+J'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DGT:2&#39;-DEOXYGUANOSINE-5&#39;-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2bq1| PDB=2bq1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bq1 OCA], [http://www.ebi.ac.uk/pdbsum/2bq1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bq1 RCSB]</span>
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}}
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'''RIBONUCLEOTIDE REDUCTASE CLASS 1B HOLOCOMPLEX R1E,R2F FROM SALMONELLA TYPHIMURIUM'''
'''RIBONUCLEOTIDE REDUCTASE CLASS 1B HOLOCOMPLEX R1E,R2F FROM SALMONELLA TYPHIMURIUM'''
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[[Category: Uhlin, U.]]
[[Category: Uhlin, U.]]
[[Category: Uppsten, M.]]
[[Category: Uppsten, M.]]
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[[Category: allosteric enzyme]]
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[[Category: Allosteric enzyme]]
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[[Category: allosteric regulation]]
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[[Category: Allosteric regulation]]
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[[Category: asymmetric complex]]
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[[Category: Asymmetric complex]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: class 1b]]
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[[Category: Class 1b]]
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[[Category: dna replication]]
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[[Category: Dna replication]]
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[[Category: holocomplex]]
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[[Category: Holocomplex]]
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[[Category: iron]]
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[[Category: Iron]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: r1]]
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[[Category: R1]]
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[[Category: r1e]]
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[[Category: R1e]]
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[[Category: r2]]
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[[Category: R2]]
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[[Category: r2f]]
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[[Category: R2f]]
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[[Category: radical transfer]]
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[[Category: Radical transfer]]
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[[Category: ribonucleotide reductase]]
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[[Category: Ribonucleotide reductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:38:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:01 2008''
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Revision as of 17:38, 3 May 2008

Image:2bq1.gif

Template:STRUCTURE 2bq1

RIBONUCLEOTIDE REDUCTASE CLASS 1B HOLOCOMPLEX R1E,R2F FROM SALMONELLA TYPHIMURIUM


Overview

Ribonucleotide reductase is an indispensable enzyme for all cells, since it catalyses the biosynthesis of the precursors necessary for both building and repairing DNA. The ribonucleotide reductase class I enzymes, present in all mammals as well as in many prokaryotes and DNA viruses, are composed mostly of two homodimeric proteins, R1 and R2. The reaction involves long-range radical transfer between the two proteins. Here, we present the first crystal structure of a ribonucleotide reductase R1/R2 holocomplex. The biological relevance of this complex is based on the binding of the R2 C terminus in the hydrophobic cleft of R1, an interaction proven to be crucial for enzyme activity, and by the fact that all conserved amino acid residues in R2 are facing the R1 active sites. We suggest that the asymmetric R1/R2 complex observed in the 4A crystal structure of Salmonella typhimurium ribonucleotide reductase represents an intermediate stage in the reaction cycle, and at the moment of reaction the homodimers transiently form a tight symmetric complex.

About this Structure

2BQ1 is a Protein complex structure of sequences from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

The first holocomplex structure of ribonucleotide reductase gives new insight into its mechanism of action., Uppsten M, Farnegardh M, Domkin V, Uhlin U, J Mol Biol. 2006 Jun 2;359(2):365-77. Epub 2006 Mar 31. PMID:16631785 Page seeded by OCA on Sat May 3 20:38:04 2008

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