2bra

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[[Image:2bra.gif|left|200px]]
[[Image:2bra.gif|left|200px]]
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{{Structure
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|PDB= 2bra |SIZE=350|CAPTION= <scene name='initialview01'>2bra</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2bra", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
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{{STRUCTURE_2bra| PDB=2bra | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bra OCA], [http://www.ebi.ac.uk/pdbsum/2bra PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bra RCSB]</span>
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'''STRUCTURE OF N-TERMINAL FAD BINDING MOTIF OF MOUSE MICAL'''
'''STRUCTURE OF N-TERMINAL FAD BINDING MOTIF OF MOUSE MICAL'''
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[[Category: Gabelli, S B.]]
[[Category: Gabelli, S B.]]
[[Category: Nadella, M.]]
[[Category: Nadella, M.]]
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[[Category: axon guidance]]
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[[Category: Axon guidance]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: cytoskeleton]]
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[[Category: Cytoskeleton]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: lim domain]]
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[[Category: Lim domain]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: plexin]]
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[[Category: Plexin]]
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[[Category: redox]]
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[[Category: Redox]]
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[[Category: vesicle transport]]
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[[Category: Vesicle transport]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:41:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:39 2008''
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Revision as of 17:41, 3 May 2008

Image:2bra.gif

Template:STRUCTURE 2bra

STRUCTURE OF N-TERMINAL FAD BINDING MOTIF OF MOUSE MICAL


Overview

During development, neurons are guided to their targets by short- and long-range attractive and repulsive cues. MICAL, a large multidomain protein, is required for the combined action of semaphorins and plexins in axon guidance. Here, we present the structure of the N-terminal region of MICAL (MICAL(fd)) determined by x-ray diffraction to 2.0 A resolution. The structure shows that MICAL(fd) is an FAD-containing module structurally similar to aromatic hydroxylases and amine oxidases. In addition, we present biochemical data that show that MICAL(fd) is a flavoenzyme that in the presence of NADPH reduces molecular oxygen to H(2)O(2) (K(m,NAPDH) = 222 microM; k(cat) = 77 sec(-1)), a molecule with known signaling properties. We propose that the H(2)O(2) produced by this reaction may be one of the signaling molecules involved in axon guidance by MICAL.

About this Structure

2BRA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure and activity of the axon guidance protein MICAL., Nadella M, Bianchet MA, Gabelli SB, Barrila J, Amzel LM, Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16830-5. Epub 2005 Nov 7. PMID:16275926 Page seeded by OCA on Sat May 3 20:41:01 2008

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