2brs

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[[Image:2brs.jpg|left|200px]]
[[Image:2brs.jpg|left|200px]]
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{{Structure
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|PDB= 2brs |SIZE=350|CAPTION= <scene name='initialview01'>2brs</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2brs", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Sgn+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IDU:1,4-DIDEOXY-O2-SULFO-GLUCURONIC+ACID'>IDU</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_2brs| PDB=2brs | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2brs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2brs OCA], [http://www.ebi.ac.uk/pdbsum/2brs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2brs RCSB]</span>
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'''EMBP HEPARIN COMPLEX'''
'''EMBP HEPARIN COMPLEX'''
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[[Category: Ohnuki, L E.]]
[[Category: Ohnuki, L E.]]
[[Category: Swaminathan, G J.]]
[[Category: Swaminathan, G J.]]
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[[Category: antibiotic]]
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[[Category: Antibiotic]]
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[[Category: embp]]
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[[Category: Embp]]
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[[Category: eosinophil]]
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[[Category: Eosinophil]]
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[[Category: eosinophil granule protein]]
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[[Category: Eosinophil granule protein]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: heparin]]
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[[Category: Heparin]]
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[[Category: heparin-binding]]
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[[Category: Heparin-binding]]
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[[Category: immune response]]
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[[Category: Immune response]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: proteoglycan]]
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[[Category: Proteoglycan]]
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[[Category: signal]]
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[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:42:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:49 2008''
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Revision as of 17:42, 3 May 2008

Image:2brs.jpg

Template:STRUCTURE 2brs

EMBP HEPARIN COMPLEX


Overview

The eosinophil major basic protein (EMBP), a constituent of the eosinophil secondary granule, is implicated in cytotoxicity and mediation of allergic disorders such as asthma. It is a member of the C-type lectin family, but lacks a Ca(2+)- and carbohydrate-binding site as seen in other members of this family. Here, we report the crystal structure of EMBP in complex with a heparin disaccharide and in the absence of Ca(2+), the first such report of any C-lectin with this sugar. We also provide direct evidence of binding of EMBP to heparin and heparin disaccharide by surface plasmon resonance. We propose that the sugars recognized by EMBP are likely to be proteoglycans such as heparin, leading to new interpretations for EMBP function.

About this Structure

2BRS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Eosinophil-granule major basic protein, a C-type lectin, binds heparin., Swaminathan GJ, Myszka DG, Katsamba PS, Ohnuki LE, Gleich GJ, Acharya KR, Biochemistry. 2005 Nov 1;44(43):14152-8. PMID:16245931 Page seeded by OCA on Sat May 3 20:42:30 2008

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