2bs2

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[[Image:2bs2.gif|left|200px]]
[[Image:2bs2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bs2 |SIZE=350|CAPTION= <scene name='initialview01'>2bs2</scene>, resolution 1.78&Aring;
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The line below this paragraph, containing "STRUCTURE_2bs2", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=FMR:FUMARATE'>FMR</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bs2| PDB=2bs2 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bs2 OCA], [http://www.ebi.ac.uk/pdbsum/2bs2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bs2 RCSB]</span>
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}}
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'''QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES'''
'''QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES'''
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==About this Structure==
==About this Structure==
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2BS2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Wolinella_succinogenes Wolinella succinogenes]. This structure supersedes the now removed PDB entry 1QLA. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BS2 OCA].
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2BS2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Wolinella_succinogenes Wolinella succinogenes]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qla 1qla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BS2 OCA].
==Reference==
==Reference==
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[[Category: 3fe-4]]
[[Category: 3fe-4]]
[[Category: 4fe-4]]
[[Category: 4fe-4]]
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[[Category: citric acid cycle]]
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[[Category: Citric acid cycle]]
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[[Category: dihaem cytochrome b]]
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[[Category: Dihaem cytochrome b]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: fumarate reductase]]
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[[Category: Fumarate reductase]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: ion-sulphur protein]]
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[[Category: Ion-sulphur protein]]
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[[Category: iron]]
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[[Category: Iron]]
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[[Category: iron-sulfur]]
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[[Category: Iron-sulfur]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: respiratory chain]]
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[[Category: Respiratory chain]]
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[[Category: succinate dehydrogenase]]
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[[Category: Succinate dehydrogenase]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: tricarboxylic acid cycle]]
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[[Category: Tricarboxylic acid cycle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:43:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:56 2008''
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Revision as of 17:43, 3 May 2008

See User added comments
Image:2bs2.gif

Template:STRUCTURE 2bs2

QUINOL:FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES


Overview

Membrane protein complexes can support both the generation and utilisation of a transmembrane electrochemical proton potential ('proton-motive force'), either by transmembrane electron transfer coupled to protolytic reactions on opposite sides of the membrane or by transmembrane proton transfer. Here we provide the first evidence that both of these mechanisms are combined in the case of a specific respiratory membrane protein complex, the dihaem-containing quinol:fumarate reductase (QFR) of Wolinella succinogenes, so as to facilitate transmembrane electron transfer by transmembrane proton transfer. We also demonstrate the non-functionality of this novel transmembrane proton transfer pathway ('E-pathway') in a variant QFR where a key glutamate residue has been replaced. The 'E-pathway', discussed on the basis of the 1.78-Angstrom-resolution crystal structure of QFR, can be concluded to be essential also for the viability of pathogenic varepsilon-proteobacteria such as Helicobacter pylori and is possibly relevant to proton transfer in other dihaem-containing membrane proteins, performing very different physiological functions.

About this Structure

2BS2 is a Protein complex structure of sequences from Wolinella succinogenes. This structure supersedes the now removed PDB entry 1qla. Full crystallographic information is available from OCA.

Reference

Evidence for transmembrane proton transfer in a dihaem-containing membrane protein complex., Madej MG, Nasiri HR, Hilgendorff NS, Schwalbe H, Lancaster CR, EMBO J. 2006 Oct 18;25(20):4963-70. Epub 2006 Oct 5. PMID:17024183 Page seeded by OCA on Sat May 3 20:43:10 2008

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