2bt6

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[[Image:2bt6.gif|left|200px]]
[[Image:2bt6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bt6 |SIZE=350|CAPTION= <scene name='initialview01'>2bt6</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2bt6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RUA:(4&#39;-METHYL-2,2&#39;BIPYRIDINE)BIS(2,2&#39;-BIPYRIDINE)'>RUA</scene>
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|ACTIVITY=
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|DOMAIN=
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{{STRUCTURE_2bt6| PDB=2bt6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bt6 OCA], [http://www.ebi.ac.uk/pdbsum/2bt6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bt6 RCSB]</span>
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'''RU(BPY)2(MBPY)-MODIFIED BOVINE ADRENODOXIN'''
'''RU(BPY)2(MBPY)-MODIFIED BOVINE ADRENODOXIN'''
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[[Category: Mueller, J J.]]
[[Category: Mueller, J J.]]
[[Category: 2fe-2]]
[[Category: 2fe-2]]
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[[Category: bovine adrenodoxin]]
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[[Category: Bovine adrenodoxin]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: intramolecular electron transfer]]
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[[Category: Intramolecular electron transfer]]
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[[Category: iron]]
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[[Category: Iron]]
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[[Category: iron-sulfur]]
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[[Category: Iron-sulfur]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: mitochondrion]]
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[[Category: Mitochondrion]]
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[[Category: ruthenium(ii) bipyridyl complex]]
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[[Category: Transit peptide]]
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[[Category: transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:45:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:23 2008''
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Revision as of 17:45, 3 May 2008

Image:2bt6.gif

Template:STRUCTURE 2bt6

RU(BPY)2(MBPY)-MODIFIED BOVINE ADRENODOXIN


Overview

Bovine adrenodoxin (Adx) plays an important role in the electron-transfer process in the mitochondrial steroid hydroxylase system of the bovine adrenal cortex. Using electron paramagnetic resonance (EPR) spectroscopy, we showed that photoreduction of the [2Fe-2S] cluster of Adx via (4'-methyl-2,2'-bipyridine)bis(2,2'-bipyridine)ruthenium(II) [Ru(bpy)2(mbpy)] covalently attached to the protein surface can be used as a new approach to probe the "shuttle" hypothesis for the electron transfer by Adx. The 1.5 A resolution crystal structure of a 1:1 Ru(bpy)2(mbpy)-Adx(1-108) complex reveals the site of modification, Cys95, and allows to predict the possible intramolecular electron-transfer pathways within the complex. Photoreduction of uncoupled Adx, mutant Adx(1-108), and Ru(bpy)2(mbpy)-Adx(1-108) using safranin T as the mediating electron donor suggests that two electrons are transferred from the dye to Adx. The intramolecular photoreduction rate constant for the ruthenated Adx has been determined and is discussed according to the predicted pathways.

About this Structure

2BT6 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Light-induced reduction of bovine adrenodoxin via the covalently bound ruthenium(II) bipyridyl complex: intramolecular electron transfer and crystal structure., Halavaty A, Muller JJ, Contzen J, Jung C, Hannemann F, Bernhardt R, Galander M, Lendzian F, Heinemann U, Biochemistry. 2006 Jan 24;45(3):709-18. PMID:16411746 Page seeded by OCA on Sat May 3 20:45:55 2008

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