2bu9

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[[Image:2bu9.gif|left|200px]]
[[Image:2bu9.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bu9 |SIZE=350|CAPTION= <scene name='initialview01'>2bu9</scene>, resolution 1.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2bu9", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HFV:DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-L-3,3,3,3&#39;,3&#39;,3&#39;-HEXAFLUOROVALINE'>HFV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Isopenicillin-N_synthase Isopenicillin-N synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.21.3.1 1.21.3.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bu9| PDB=2bu9 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bu9 OCA], [http://www.ebi.ac.uk/pdbsum/2bu9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bu9 RCSB]</span>
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}}
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'''ISOPENICILLIN N SYNTHASE COMPLEXED WITH L-AMINOADIPOYL-L-CYSTEINYL-L-HEXAFLUOROVALINE'''
'''ISOPENICILLIN N SYNTHASE COMPLEXED WITH L-AMINOADIPOYL-L-CYSTEINYL-L-HEXAFLUOROVALINE'''
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[[Category: Howard-Jones, A R.]]
[[Category: Howard-Jones, A R.]]
[[Category: Rutledge, P J.]]
[[Category: Rutledge, P J.]]
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[[Category: antibiotic biosynthesis]]
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[[Category: Antibiotic biosynthesis]]
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[[Category: b-lactam antibiotic]]
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[[Category: B-lactam antibiotic]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: oxygenase]]
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[[Category: Oxygenase]]
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[[Category: penicillin biosynthesis]]
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[[Category: Penicillin biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:48:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:50 2008''
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Revision as of 17:48, 3 May 2008

Image:2bu9.gif

Template:STRUCTURE 2bu9

ISOPENICILLIN N SYNTHASE COMPLEXED WITH L-AMINOADIPOYL-L-CYSTEINYL-L-HEXAFLUOROVALINE


Overview

Isopenicillin N synthase (IPNS) is a non-haem iron oxidase that catalyses the formation of isopenicillin N from the tripeptide delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine. In this report, we describe the crystal structure of the enzyme with a non-natural L,L,L-tripeptide substrate, delta-(L-alpha-aminoadipoyl)-L-cysteinyl-L-3,3,3,3',3',3'-hexafluorovaline . This structure reveals a strong binding interaction of the tripeptide within the active site and a unique conformation for the non-natural L,L,L-diastereomer. Taken together, these findings provide a possible rationale for the previously observed inhibitory effects of L,L,L-tripeptide substrates on IPNS activity.

About this Structure

2BU9 is a Single protein structure of sequence from Emericella nidulans. Full crystallographic information is available from OCA.

Reference

Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase., Howard-Jones AR, Rutledge PJ, Clifton IJ, Adlington RM, Baldwin JE, Biochem Biophys Res Commun. 2005 Oct 21;336(2):702-8. PMID:16143309 Page seeded by OCA on Sat May 3 20:48:25 2008

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