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2bv7

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[[Image:2bv7.gif|left|200px]]
[[Image:2bv7.gif|left|200px]]
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{{Structure
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|PDB= 2bv7 |SIZE=350|CAPTION= <scene name='initialview01'>2bv7</scene>, resolution 1.79&Aring;
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The line below this paragraph, containing "STRUCTURE_2bv7", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gm3+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GM3:N-{1-[(HEXOPYRANOSYLOXY)METHYL]-2-HYDROXYNONADECYL}TETRACOSANAMIDE'>GM3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_2bv7| PDB=2bv7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bv7 OCA], [http://www.ebi.ac.uk/pdbsum/2bv7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bv7 RCSB]</span>
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'''CRYSTAL STRUCTURE OF GLTP WITH BOUND GM3'''
'''CRYSTAL STRUCTURE OF GLTP WITH BOUND GM3'''
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[[Category: Salminen, T A.]]
[[Category: Salminen, T A.]]
[[Category: West, G.]]
[[Category: West, G.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: glycolipid]]
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[[Category: Glycolipid]]
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[[Category: glycolipid transfer protein]]
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[[Category: Glycolipid transfer protein]]
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[[Category: ligand binding]]
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[[Category: Ligand binding]]
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[[Category: lipid transport]]
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[[Category: Lipid transport]]
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[[Category: repeat]]
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[[Category: Repeat]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:50:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:12:12 2008''
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Revision as of 17:50, 3 May 2008

Image:2bv7.gif

Template:STRUCTURE 2bv7

CRYSTAL STRUCTURE OF GLTP WITH BOUND GM3


Overview

Glycolipids participate in many important cellular processes and they are bound and transferred with high specificity by glycolipid transfer protein (GLTP). We have solved three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid. The 1.4 angstroms structure resembles the recently characterized apo-form of the human GLTP but the other two structures represent an intermediate conformation of the apo-GLTPs and the human lactosylceramide-bound GLTP structure. These novel structures give insight into the mechanism of lipid binding and how GLTP may conformationally adapt to different lipids. Furthermore, based on the structural comparison of the GLTP structures and the three-dimensional models of the related Podospora anserina HET-C2 and Arabidopsis thaliana accelerated cell death protein, ACD11, we give structural explanations for their specific lipid binding properties.

About this Structure

2BV7 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural evidence for adaptive ligand binding of glycolipid transfer protein., Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA, J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699 Page seeded by OCA on Sat May 3 20:50:44 2008

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