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5ola

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Current revision (16:53, 13 December 2023) (edit) (undo)
 
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==Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM==
==Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM==
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<StructureSection load='5ola' size='340' side='right' caption='[[5ola]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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<StructureSection load='5ola' size='340' side='right'caption='[[5ola]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ola]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OLA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ola]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OLA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TEFM, C17orf42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), POLRMT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.904&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ola FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ola OCA], [https://pdbe.org/5ola PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ola RCSB], [https://www.ebi.ac.uk/pdbsum/5ola PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ola ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ola FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ola OCA], [http://pdbe.org/5ola PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ola RCSB], [http://www.ebi.ac.uk/pdbsum/5ola PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ola ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TEFM_HUMAN TEFM_HUMAN]] Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.<ref>PMID:21278163</ref> [[http://www.uniprot.org/uniprot/RPOM_HUMAN RPOM_HUMAN]] DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.<ref>PMID:21278163</ref>
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[https://www.uniprot.org/uniprot/TEFM_HUMAN TEFM_HUMAN] Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.<ref>PMID:21278163</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ola" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ola" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Agaronyan, K]]
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[[Category: Synthetic construct]]
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[[Category: Anikin, M]]
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[[Category: Agaronyan K]]
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[[Category: Chernev, A]]
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[[Category: Anikin M]]
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[[Category: Cramer, P]]
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[[Category: Chernev A]]
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[[Category: Graber, J J]]
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[[Category: Cramer P]]
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[[Category: Hillen, H S]]
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[[Category: Graber JJ]]
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[[Category: Morozov, Y]]
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[[Category: Hillen HS]]
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[[Category: Parshin, A V]]
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[[Category: Morozov Y]]
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[[Category: Schwinghammer, K]]
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[[Category: Parshin AV]]
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[[Category: Temiakov, D]]
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[[Category: Schwinghammer K]]
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[[Category: Urlaub, H]]
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[[Category: Temiakov D]]
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[[Category: Elongation factor]]
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[[Category: Urlaub H]]
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[[Category: Mitochondria]]
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[[Category: Resolvase]]
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[[Category: Rna polymerase]]
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[[Category: Transcription]]
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Current revision

Structure of mitochondrial transcription elongation complex in complex with elongation factor TEFM

PDB ID 5ola

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