2bzg

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[[Image:2bzg.gif|left|200px]]
[[Image:2bzg.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bzg |SIZE=350|CAPTION= <scene name='initialview01'>2bzg</scene>, resolution 1.58&Aring;
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The line below this paragraph, containing "STRUCTURE_2bzg", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:B3p+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiopurine_S-methyltransferase Thiopurine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.67 2.1.1.67] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam05724 TPMT]</span>
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{{STRUCTURE_2bzg| PDB=2bzg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzg OCA], [http://www.ebi.ac.uk/pdbsum/2bzg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bzg RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.'''
'''CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.'''
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[[Category: Wu, H.]]
[[Category: Wu, H.]]
[[Category: Zeng, H.]]
[[Category: Zeng, H.]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomics consortium (sgc)]]
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[[Category: Transferase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:06 2008''
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Revision as of 18:00, 3 May 2008

Image:2bzg.gif

Template:STRUCTURE 2bzg

CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.


Overview

Human thiopurine S-methyltransferase (TPMT) exhibits considerable person-to-person variation in activity to thiopurine drugs. We have produced an N-terminal truncation of human TPMT protein, crystallized the protein in complex with the methyl donor product S-adenosyl-L-homocysteine, and determined the atomic structure to the resolution of 1.58 and 1.89 A, respectively, for the seleno-methionine incorporated and wild type proteins. The structure of TPMT indicates that the naturally occurring amino acid polymorphisms scatter throughout the structure, and that the amino acids whose alteration have the most influence on function are those that form intra-molecular stabilizing interactions (mainly van der Waals contacts). Furthermore, we have produced four TPMT mutant proteins containing variant alleles of TPMT*2, *3A, *3B, and *3C and examined the structure-function relationship of the mutant proteins based on their expression and solubility in bacteria and their thermostability profile.

About this Structure

2BZG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of allele variation of human thiopurine-S-methyltransferase., Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X, Proteins. 2007 Apr 1;67(1):198-208. PMID:17243178 Page seeded by OCA on Sat May 3 21:00:49 2008

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