2bzf

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[[Image:2bzf.gif|left|200px]]
[[Image:2bzf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2bzf |SIZE=350|CAPTION= <scene name='initialview01'>2bzf</scene>, resolution 2.87&Aring;
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The line below this paragraph, containing "STRUCTURE_2bzf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2bzf| PDB=2bzf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzf OCA], [http://www.ebi.ac.uk/pdbsum/2bzf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bzf RCSB]</span>
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}}
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'''STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)'''
'''STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)'''
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[[Category: Ghirlando, R.]]
[[Category: Ghirlando, R.]]
[[Category: Ronning, D R.]]
[[Category: Ronning, D R.]]
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[[Category: dna compaction]]
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[[Category: Dna compaction]]
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[[Category: lem family]]
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[[Category: Lem family]]
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[[Category: non-specific dna-binding]]
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[[Category: Non-specific dna-binding]]
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[[Category: nuclear organization]]
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[[Category: Nuclear organization]]
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[[Category: retroviral integration]]
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[[Category: Retroviral integration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:05 2008''
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Revision as of 18:00, 3 May 2008

Image:2bzf.gif

Template:STRUCTURE 2bzf

STRUCTURAL BASIS FOR DNA BRIDGING BY BARRIER-TO-AUTOINTEGRATION FACTOR (BAF)


Overview

The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation.

About this Structure

2BZF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for DNA bridging by barrier-to-autointegration factor., Bradley CM, Ronning DR, Ghirlando R, Craigie R, Dyda F, Nat Struct Mol Biol. 2005 Oct;12(10):935-6. Epub 2005 Sep 11. PMID:16155580 Page seeded by OCA on Sat May 3 21:00:49 2008

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