2c0n
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2c0n.gif|left|200px]] | [[Image:2c0n.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2c0n", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | | | + | {{STRUCTURE_2c0n| PDB=2c0n | SCENE= }} |
| - | | | + | |
| - | + | ||
| - | }} | + | |
'''CRYSTAL STRUCTURE OF A197 FROM STIV''' | '''CRYSTAL STRUCTURE OF A197 FROM STIV''' | ||
| Line 29: | Line 26: | ||
[[Category: Reiter, D.]] | [[Category: Reiter, D.]] | ||
[[Category: Young, M.]] | [[Category: Young, M.]] | ||
| - | [[Category: | + | [[Category: Archaea]] |
| - | [[Category: | + | [[Category: Archaeal virus]] |
| - | [[Category: | + | [[Category: Crenarchaea]] |
| - | [[Category: | + | [[Category: Crenarchaeal virus]] |
| - | [[Category: | + | [[Category: Glycosyltransferase]] |
| - | [[Category: | + | [[Category: Stiv]] |
| - | [[Category: | + | [[Category: Sulfolobus]] |
| - | [[Category: | + | [[Category: Sulfolobus turreted icosahedral virus]] |
| - | [[Category: | + | [[Category: Thermophilic protein]] |
| - | [[Category: | + | [[Category: Thermophilic virus]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | [[Category: | + | [[Category: Viral protein]] |
| - | [[Category: | + | [[Category: Virus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:03:54 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:03, 3 May 2008
CRYSTAL STRUCTURE OF A197 FROM STIV
Overview
Sulfolobus turreted icosahedral virus (STIV) was the first icosahedral virus characterized from an archaeal host. It infects Sulfolobus species that thrive in the acidic hot springs (pH 2.9 to 3.9 and 72 to 92 degrees C) of Yellowstone National Park. The overall capsid architecture and the structure of its major capsid protein are very similar to those of the bacteriophage PRD1 and eukaryotic viruses Paramecium bursaria Chlorella virus 1 and adenovirus, suggesting a viral lineage that predates the three domains of life. The 17,663-base-pair, circular, double-stranded DNA genome contains 36 potential open reading frames, whose sequences generally show little similarity to other genes in the sequence databases. However, functional and evolutionary information may be suggested by a protein's three-dimensional structure. To this end, we have undertaken structural studies of the STIV proteome. Here we report our work on A197, the product of an STIV open reading frame. The structure of A197 reveals a GT-A fold that is common to many members of the glycosyltransferase superfamily. A197 possesses a canonical DXD motif and a putative catalytic base that are hallmarks of this family of enzymes, strongly suggesting a glycosyltransferase activity for A197. Potential roles for the putative glycosyltransferase activity of A197 and their evolutionary implications are discussed.
About this Structure
2C0N is a Single protein structure of sequence from Sulfolobus turreted icosahedral virus. Full crystallographic information is available from OCA.
Reference
Structure of A197 from Sulfolobus turreted icosahedral virus: a crenarchaeal viral glycosyltransferase exhibiting the GT-A fold., Larson ET, Reiter D, Young M, Lawrence CM, J Virol. 2006 Aug;80(15):7636-44. PMID:16840342 Page seeded by OCA on Sat May 3 21:03:54 2008
Categories: Single protein | Sulfolobus turreted icosahedral virus | Larson, E T. | Lawrence, C M. | Reiter, D. | Young, M. | Archaea | Archaeal virus | Crenarchaea | Crenarchaeal virus | Glycosyltransferase | Stiv | Sulfolobus | Thermophilic protein | Thermophilic virus | Transferase | Viral protein | Virus
