2c0i

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[[Image:2c0i.gif|left|200px]]
[[Image:2c0i.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2c0i |SIZE=350|CAPTION= <scene name='initialview01'>2c0i</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2c0i", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=L1G:N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE'>L1G</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2c0i| PDB=2c0i | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0i OCA], [http://www.ebi.ac.uk/pdbsum/2c0i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c0i RCSB]</span>
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}}
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'''SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983'''
'''SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983'''
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[[Category: Li, B.]]
[[Category: Li, B.]]
[[Category: Loew, A.]]
[[Category: Loew, A.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: myristate]]
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[[Category: Myristate]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: palmitate]]
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[[Category: Palmitate]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: sh2 domain]]
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[[Category: Sh2 domain]]
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[[Category: sh3 domain]]
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[[Category: Sh3 domain]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: tyrosine-protein kinase]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:03:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:35 2008''
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Revision as of 18:03, 3 May 2008

Image:2c0i.gif

Template:STRUCTURE 2c0i

SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-420983


Overview

We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.

About this Structure

2C0I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497 Page seeded by OCA on Sat May 3 21:03:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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