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2c1h

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[[Image:2c1h.jpg|left|200px]]
[[Image:2c1h.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2c1h |SIZE=350|CAPTION= <scene name='initialview01'>2c1h</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2c1h", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Dsb+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DSB:4,7-DIOXOSEBACIC+ACID'>DSB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2c1h| PDB=2c1h | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1h OCA], [http://www.ebi.ac.uk/pdbsum/2c1h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c1h RCSB]</span>
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}}
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'''THE X-RAY STRUCTURE OF CHLOROBIUM VIBRIOFORME 5-AMINOLAEVULINIC ACID DEHYDRATASE COMPLEXED WITH A DIACID INHIBITOR'''
'''THE X-RAY STRUCTURE OF CHLOROBIUM VIBRIOFORME 5-AMINOLAEVULINIC ACID DEHYDRATASE COMPLEXED WITH A DIACID INHIBITOR'''
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[[Category: Wood, S P.]]
[[Category: Wood, S P.]]
[[Category: 5-aminolaevulinic acid dehydratase]]
[[Category: 5-aminolaevulinic acid dehydratase]]
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[[Category: alad]]
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[[Category: Alad]]
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[[Category: heme biosynthesis]]
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[[Category: Heme biosynthesis]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: magnesium]]
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[[Category: Magnesium]]
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[[Category: porphyrin biosynthesis]]
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[[Category: Porphyrin biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:06:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:59 2008''
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Revision as of 18:06, 3 May 2008

Image:2c1h.jpg

Template:STRUCTURE 2c1h

THE X-RAY STRUCTURE OF CHLOROBIUM VIBRIOFORME 5-AMINOLAEVULINIC ACID DEHYDRATASE COMPLEXED WITH A DIACID INHIBITOR


Overview

The structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase (ALAD) complexed with the irreversible inhibitor 4,7-dioxosebacic acid has been solved. The inhibitor binds by forming Schiff-base linkages with lysines 200 and 253 at the active site. The structure reported here provides a definition of the interactions made by both of the substrate molecules (A-side and P-side substrates) with the C. vibrioforme ALAD and is compared and contrasted with structures of the same inhibitor bound to Escherichia coli and yeast ALAD. The structure suggests why 4,7-dioxosebacic acid is a better inhibitor of the zinc-dependent ALADs than of the zinc-independent ALADs.

About this Structure

2C1H is a Single protein structure of sequence from Prosthecochloris vibrioformis. Full crystallographic information is available from OCA.

Reference

Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor., Coates L, Beaven G, Erskine PT, Beale SI, Wood SP, Shoolingin-Jordan PM, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1594-8. Epub 2005, Nov 19. PMID:16304458 Page seeded by OCA on Sat May 3 21:06:17 2008

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