6f58

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m (Protected "6f58" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6f58 is ON HOLD
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==Crystal structure of human Brachyury (T) in complex with DNA==
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<StructureSection load='6f58' size='340' side='right' caption='[[6f58]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Newman, J.A., Gavard, A.E., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6f58]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F58 FirstGlance]. <br>
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Description: Crystal structure of human Brachyury (T) in complex with DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f58 OCA], [http://pdbe.org/6f58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f58 RCSB], [http://www.ebi.ac.uk/pdbsum/6f58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f58 ProSAT]</span></td></tr>
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[[Category: Arrowsmith, C.H]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/BRAC_HUMAN BRAC_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/BRAC_HUMAN BRAC_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A]]
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[[Category: Gavard, A E]]
[[Category: Gileadi, O]]
[[Category: Gileadi, O]]
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[[Category: Newman, J.A]]
 
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[[Category: Edwards, A]]
 
[[Category: Krojer, T]]
[[Category: Krojer, T]]
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[[Category: Gavard, A.E]]
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[[Category: Newman, J A]]
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[[Category: Von Delft, F]]
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[[Category: Shrestha, L]]
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[[Category: Bountra, C]]
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[[Category: Brachyury]]
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[[Category: Chordoma]]
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[[Category: T-box]]
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[[Category: Transcription]]

Revision as of 07:06, 13 December 2017

Crystal structure of human Brachyury (T) in complex with DNA

6f58, resolution 2.25Å

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