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5hkf

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Current revision (10:44, 16 August 2023) (edit) (undo)
 
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==Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)==
==Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)==
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<StructureSection load='5hkf' size='340' side='right' caption='[[5hkf]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='5hkf' size='340' side='right'caption='[[5hkf]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hkf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HKF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hkf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HKF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pyrE, umpA, Rv0382c, MTV036.17c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hkf OCA], [https://pdbe.org/5hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hkf RCSB], [https://www.ebi.ac.uk/pdbsum/5hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hkf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hkf OCA], [http://pdbe.org/5hkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hkf RCSB], [http://www.ebi.ac.uk/pdbsum/5hkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hkf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYRE_MYCTU PYRE_MYCTU]] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
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[https://www.uniprot.org/uniprot/PYRE_MYCTU PYRE_MYCTU] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5hkf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5hkf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Orotate phosphoribosyltransferase]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Bolognesi, G]]
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[[Category: Bolognesi G]]
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[[Category: Donini, S]]
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[[Category: Donini S]]
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[[Category: Ferraris, D M]]
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[[Category: Ferraris DM]]
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[[Category: Rizzi, M]]
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[[Category: Rizzi M]]
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[[Category: De novo pyrimidine nucleotide synthesis]]
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[[Category: Oprt]]
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[[Category: Prpp complex]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)

PDB ID 5hkf

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