This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2c5d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2c5d.gif|left|200px]]
[[Image:2c5d.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2c5d |SIZE=350|CAPTION= <scene name='initialview01'>2c5d</scene>, resolution 3.3&Aring;
+
The line below this paragraph, containing "STRUCTURE_2c5d", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Chain+B'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2c5d| PDB=2c5d | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5d OCA], [http://www.ebi.ac.uk/pdbsum/2c5d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c5d RCSB]</span>
+
-
}}
+
'''STRUCTURE OF A MINIMAL GAS6-AXL COMPLEX'''
'''STRUCTURE OF A MINIMAL GAS6-AXL COMPLEX'''
Line 34: Line 31:
[[Category: Timpl, R.]]
[[Category: Timpl, R.]]
[[Category: Ullrich, A.]]
[[Category: Ullrich, A.]]
-
[[Category: egf-like domain]]
+
[[Category: Egf-like domain]]
-
[[Category: growth regulation]]
+
[[Category: Growth regulation]]
-
[[Category: immunoglobulin-like domain]]
+
[[Category: Immunoglobulin-like domain]]
-
[[Category: laminin g-like domain]]
+
[[Category: Laminin g-like domain]]
-
[[Category: receptor]]
+
[[Category: Receptor]]
-
[[Category: receptor tyrosine kinase]]
+
[[Category: Receptor tyrosine kinase]]
-
[[Category: vitamin k-dependent protein]]
+
[[Category: Vitamin k-dependent protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:16:38 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:35 2008''
+

Revision as of 18:16, 3 May 2008

Image:2c5d.gif

Template:STRUCTURE 2c5d

STRUCTURE OF A MINIMAL GAS6-AXL COMPLEX


Overview

Receptor tyrosine kinases of the Axl family are activated by the vitamin K-dependent protein Gas6. Axl signalling plays important roles in cancer, spermatogenesis, immunity, and platelet function. The crystal structure at 3.3 A resolution of a minimal human Gas6/Axl complex reveals an assembly of 2:2 stoichiometry, in which the two immunoglobulin-like domains of the Axl ectodomain are crosslinked by the first laminin G-like domain of Gas6, with no direct Axl/Axl or Gas6/Gas6 contacts. There are two distinct Gas6/Axl contacts of very different size, both featuring interactions between edge beta-strands. Structure-based mutagenesis, protein binding assays and receptor activation experiments demonstrate that both the major and minor Gas6 binding sites are required for productive transmembrane signalling. Gas6-mediated Axl dimerisation is likely to occur in two steps, with a high-affinity 1:1 Gas6/Axl complex forming first. Only the minor Gas6 binding site is highly conserved in the other Axl family receptors, Sky/Tyro3 and Mer. Specificity at the major contact is suggested to result from the segregation of charged and apolar residues to opposite faces of the newly formed beta-sheet.

About this Structure

2C5D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for Gas6-Axl signalling., Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Gohring W, Ullrich A, Timpl R, Hohenester E, EMBO J. 2006 Jan 11;25(1):80-7. Epub 2005 Dec 15. PMID:16362042 Page seeded by OCA on Sat May 3 21:16:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c5d"
Personal tools