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5x49

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Current revision (10:07, 15 November 2023) (edit) (undo)
 
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==Crystal Structure of Human mitochondrial X-prolyl Aminopeptidase (XPNPEP3)==
==Crystal Structure of Human mitochondrial X-prolyl Aminopeptidase (XPNPEP3)==
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<StructureSection load='5x49' size='340' side='right' caption='[[5x49]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='5x49' size='340' side='right'caption='[[5x49]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5x49]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X49 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5x49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X49 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=01B:(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOIC+ACID'>01B</scene>, <scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XPNPEP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=01B:(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOIC+ACID'>01B</scene>, <scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x49 OCA], [https://pdbe.org/5x49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x49 RCSB], [https://www.ebi.ac.uk/pdbsum/5x49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x49 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x49 OCA], [http://pdbe.org/5x49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x49 RCSB], [http://www.ebi.ac.uk/pdbsum/5x49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x49 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/XPP3_HUMAN XPP3_HUMAN]] Late-onset nephronophthisis. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/XPP3_HUMAN XPP3_HUMAN] Late-onset nephronophthisis. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/XPP3_HUMAN XPP3_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Xaa-Pro aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Ghosh, B]]
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[[Category: Ghosh B]]
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[[Category: Jamdar, S]]
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[[Category: Jamdar S]]
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[[Category: Kumar, A]]
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[[Category: Kumar A]]
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[[Category: Makde, R D]]
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[[Category: Makde RD]]
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[[Category: Singh, R]]
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[[Category: Singh R]]
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[[Category: Hydrolase]]
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[[Category: Icp55]]
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[[Category: M24b]]
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[[Category: X-prolyl aminopeptidase]]
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[[Category: Xpnpep3]]
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Current revision

Crystal Structure of Human mitochondrial X-prolyl Aminopeptidase (XPNPEP3)

PDB ID 5x49

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