2c5l

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[[Image:2c5l.gif|left|200px]]
[[Image:2c5l.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2c5l |SIZE=350|CAPTION= <scene name='initialview01'>2c5l</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2c5l", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+C'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Small_monomeric_GTPase Small monomeric GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.2 3.6.5.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2c5l| PDB=2c5l | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5l OCA], [http://www.ebi.ac.uk/pdbsum/2c5l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c5l RCSB]</span>
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'''STRUCTURE OF PLC EPSILON RAS ASSOCIATION DOMAIN WITH HRAS'''
'''STRUCTURE OF PLC EPSILON RAS ASSOCIATION DOMAIN WITH HRAS'''
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[[Category: Pearl, L H.]]
[[Category: Pearl, L H.]]
[[Category: Roe, S M.]]
[[Category: Roe, S M.]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: gtp-binding]]
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[[Category: Gtp-binding]]
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[[Category: lipoprotein]]
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[[Category: Lipoprotein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: oncogene]]
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[[Category: Oncogene]]
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[[Category: palmitate]]
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[[Category: Palmitate]]
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[[Category: prenylation]]
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[[Category: Prenylation]]
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[[Category: proto-oncogene]]
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[[Category: Proto-oncogene]]
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[[Category: ra]]
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[[Category: Ra]]
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[[Category: signaling protein]]
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[[Category: Signaling protein]]
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[[Category: ubiquitin superfold]]
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[[Category: Ubiquitin superfold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:17:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:43 2008''
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Revision as of 18:17, 3 May 2008

Image:2c5l.gif

Template:STRUCTURE 2c5l

STRUCTURE OF PLC EPSILON RAS ASSOCIATION DOMAIN WITH HRAS


Overview

Ras proteins signal to a number of distinct pathways by interacting with diverse effectors. Studies of ras/effector interactions have focused on three classes, Raf kinases, ral guanylnucleotide-exchange factors, and phosphatidylinositol-3-kinases. Here we describe ras interactions with another effector, the recently identified phospholipase C epsilon (PLCepsilon). We solved structures of PLCepsilon RA domains (RA1 and RA2) by NMR and the structure of the RA2/ras complex by X-ray crystallography. Although the similarity between ubiquitin-like folds of RA1 and RA2 proves that they are homologs, only RA2 can bind ras. Some of the features of the RA2/ras interface are unique to PLCepsilon, while the ability to make contacts with both switch I and II regions of ras is shared only with phosphatidylinositol-3-kinase. Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity.

About this Structure

2C5L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural and mechanistic insights into ras association domains of phospholipase C epsilon., Bunney TD, Harris R, Gandarillas NL, Josephs MB, Roe SM, Sorli SC, Paterson HF, Rodrigues-Lima F, Esposito D, Ponting CP, Gierschik P, Pearl LH, Driscoll PC, Katan M, Mol Cell. 2006 Feb 17;21(4):495-507. PMID:16483931 Page seeded by OCA on Sat May 3 21:17:17 2008

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OCA

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