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2c62

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[[Image:2c62.gif|left|200px]]
[[Image:2c62.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2c62 |SIZE=350|CAPTION= <scene name='initialview01'>2c62</scene>, resolution 1.74&Aring;
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The line below this paragraph, containing "STRUCTURE_2c62", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|DOMAIN=
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{{STRUCTURE_2c62| PDB=2c62 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c62 OCA], [http://www.ebi.ac.uk/pdbsum/2c62 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c62 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA'''
'''CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA'''
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[[Category: Moras, D.]]
[[Category: Moras, D.]]
[[Category: Werten, S.]]
[[Category: Werten, S.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: dna unwinding]]
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[[Category: Dna unwinding]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: single-stranded dna]]
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[[Category: Single-stranded dna]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription cofactor]]
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[[Category: Transcription cofactor]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:18:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:16:51 2008''
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Revision as of 18:18, 3 May 2008

Image:2c62.gif

Template:STRUCTURE 2c62

CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA


Overview

The 1.74-A crystal structure of the human transcription cofactor PC4 in complex with a single-stranded 20-mer oligonucleotide reveals how symmetry-related beta-surfaces of the protein homodimer interact with juxtaposed 5-nucleotide DNA regions running in opposite directions. The structure explains high-affinity binding of PC4 to the complementary strands of unwinding duplex DNA, and it suggests the cofactor may have a role in relaxing negative supercoils or exposing unpaired bases for sequence-specific recognition by other biomolecules.

About this Structure

2C62 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A global transcription cofactor bound to juxtaposed strands of unwound DNA., Werten S, Moras D, Nat Struct Mol Biol. 2006 Feb;13(2):181-2. Epub 2006 Jan 15. PMID:16415882 Page seeded by OCA on Sat May 3 21:18:33 2008

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