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5nxj
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==SH3 domain from Mouse cortactin (P 1 21 1 crystal form)== | |
| - | + | <StructureSection load='5nxj' size='340' side='right' caption='[[5nxj]], [[Resolution|resolution]] 2.28Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nxj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NXJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nxj OCA], [http://pdbe.org/5nxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nxj RCSB], [http://www.ebi.ac.uk/pdbsum/5nxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nxj ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE]] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dessau, M]] | ||
[[Category: Twafra, S]] | [[Category: Twafra, S]] | ||
| - | [[Category: | + | [[Category: Cancer]] |
| + | [[Category: Cortactin]] | ||
| + | [[Category: Invadopodium]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Sh3 domain]] | ||
| + | [[Category: Signaling]] | ||
Revision as of 05:25, 30 May 2018
SH3 domain from Mouse cortactin (P 1 21 1 crystal form)
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Categories: Dessau, M | Twafra, S | Cancer | Cortactin | Invadopodium | Protein binding | Sh3 domain | Signaling
