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5wno
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of C. elegans LET-23 kinase domain complexed with AMP-PNP== | |
| - | + | <StructureSection load='5wno' size='340' side='right' caption='[[5wno]], [[Resolution|resolution]] 2.39Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5wno]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wno OCA], [http://pdbe.org/5wno PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wno RCSB], [http://www.ebi.ac.uk/pdbsum/5wno PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wno ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LET23_CAEEL LET23_CAEEL]] Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis (PubMed:2071015, PubMed:8313880, PubMed:9491893). Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade downstream of ligand lin-3, plays a role in ovulation by promoting ovulatory gonadal sheath cell contractions (PubMed:9491893, PubMed:15194811). Probably by regulating neuronal transmission in ALA neurons, mediates, independently of let-60/Ras, the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and upstream of plc-3 (PubMed:17891142).<ref>PMID:15194811</ref> <ref>PMID:17891142</ref> <ref>PMID:2071015</ref> <ref>PMID:8313880</ref> <ref>PMID:9491893</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Receptor protein-tyrosine kinase]] | ||
[[Category: Jura, N]] | [[Category: Jura, N]] | ||
[[Category: Liu, L]] | [[Category: Liu, L]] | ||
| - | [[Category: Thaker, T | + | [[Category: Thaker, T M]] |
| + | [[Category: C. elegan]] | ||
| + | [[Category: Cell signaling]] | ||
| + | [[Category: Dimerization]] | ||
| + | [[Category: Inactive conformation]] | ||
| + | [[Category: Let-23]] | ||
| + | [[Category: Receptor tyrosine-protein kinase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:52, 31 January 2018
Crystal structure of C. elegans LET-23 kinase domain complexed with AMP-PNP
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