6bom
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.== | |
| - | + | <StructureSection load='6bom' size='340' side='right' caption='[[6bom]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bom]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfc Aspfc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mcsA, AFUB_094700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=451804 ASPFC])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bom OCA], [http://pdbe.org/6bom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bom RCSB], [http://www.ebi.ac.uk/pdbsum/6bom PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bom ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRPC_ASPFC PRPC_ASPFC]] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. Plays a key role in the estabishment of invasive pulmonary aspergillosis.<ref>PMID:17973657</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aspfc]] | ||
[[Category: Chruszcz, M]] | [[Category: Chruszcz, M]] | ||
[[Category: Schlachter, C]] | [[Category: Schlachter, C]] | ||
| + | [[Category: 2-methylcitrate synthase]] | ||
| + | [[Category: Citrate synthase]] | ||
| + | [[Category: Mcsa]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 20:24, 2 December 2018
Crystal structure of mutant 2-methylcitrate synthase mcsAG306A from Aspergillus fumigatus.
| |||||||||||
