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6bsf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human GR (418-507) in complex with monomeric DNA binding site== | |
| - | + | <StructureSection load='6bsf' size='340' side='right' caption='[[6bsf]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bsf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsf OCA], [http://pdbe.org/6bsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bsf RCSB], [http://www.ebi.ac.uk/pdbsum/6bsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsf ProSAT]</span></td></tr> |
| - | [[Category: Pufall, M | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GCR_SAGOE GCR_SAGOE]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.[UniProtKB:P04150][UniProtKB:P06537] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Pufall, M A]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Glucocorticoid receptor monomeric binding site]] | ||
Revision as of 06:33, 5 December 2018
Human GR (418-507) in complex with monomeric DNA binding site
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