6f5f
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of ARTD2/PARP2 WGR domain bound to double strand DNA with 5 nucleotide overhang and 5'phosphate== | |
| - | + | <StructureSection load='6f5f' size='340' side='right' caption='[[6f5f]], [[Resolution|resolution]] 2.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f5f]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F5F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f5f OCA], [http://pdbe.org/6f5f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f5f RCSB], [http://www.ebi.ac.uk/pdbsum/6f5f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f5f ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Haikarainen, T]] | ||
| + | [[Category: Lehtio, L]] | ||
| + | [[Category: Obaji, E]] | ||
| + | [[Category: Adp-ribosylation]] | ||
| + | [[Category: Artd2]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna end joining]] | ||
| + | [[Category: Dna repair]] | ||
| + | [[Category: Non-phosphorylated dna]] | ||
Revision as of 08:11, 10 October 2018
Structure of ARTD2/PARP2 WGR domain bound to double strand DNA with 5 nucleotide overhang and 5'phosphate
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