2c9n
From Proteopedia
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'''STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION''' | '''STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION''' | ||
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[[Category: Muller, C W.]] | [[Category: Muller, C W.]] | ||
[[Category: Petosa, C.]] | [[Category: Petosa, C.]] | ||
| - | [[Category: | + | [[Category: Bzip protein]] |
| - | [[Category: | + | [[Category: Bzlf1]] |
| - | [[Category: | + | [[Category: Ebv]] |
| - | [[Category: | + | [[Category: Epstein-barr virus]] |
| - | [[Category: | + | [[Category: Lytic cycle activation]] |
| - | [[Category: | + | [[Category: Nuclear protein]] |
| - | [[Category: | + | [[Category: Transcription regulation]] |
| - | [[Category: | + | [[Category: Viral protein dna-binding]] |
| - | [[Category: | + | [[Category: Zebra]] |
| - | [[Category: | + | [[Category: Zta]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:31:12 2008'' | |
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Revision as of 18:31, 3 May 2008
STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION
Overview
Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several human malignancies. EBV has a biphasic infection cycle consisting of a latent and a lytic, replicative phase. The switch from latent to lytic infection is triggered by the EBV immediate-early transcription factor ZEBRA (BZLF1, Zta, Z, EB1). We present the crystal structure of ZEBRA's DNA binding domain bound to an EBV lytic gene promoter element. ZEBRA exhibits a variant of the basic-region leucine zipper (bZIP) fold in which a C-terminal moiety stabilizes the coiled coil involved in dimer formation. The structure provides insights into ZEBRA's broad target site specificity, preferential activation of specific EBV promoters in their methylated state, ability to dimerize despite lacking a leucine zipper motif, and failure to heterodimerize with cellular bZIP proteins. The structure will allow for the design of new therapeutic agents that block activation of the EBV lytic cycle.
About this Structure
2C9N is a Protein complex structure of sequences from Human herpesvirus 4. Full crystallographic information is available from OCA.
Reference
Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein., Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW, Mol Cell. 2006 Feb 17;21(4):565-72. PMID:16483937 Page seeded by OCA on Sat May 3 21:31:12 2008
