2cde

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[[Image:2cde.gif|left|200px]]
[[Image:2cde.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cde OCA], [http://www.ebi.ac.uk/pdbsum/2cde PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cde RCSB]</span>
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'''STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE SPECIFIC T CELL RECEPTORS-INKT-TCR'''
'''STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE SPECIFIC T CELL RECEPTORS-INKT-TCR'''
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[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
[[Category: Villiger, P M.]]
[[Category: Villiger, P M.]]
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[[Category: alpha-galactosylceramide]]
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[[Category: Alpha-galactosylceramide]]
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[[Category: cd1d]]
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[[Category: Cd1d]]
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[[Category: mhc class i]]
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[[Category: Mhc class i]]
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[[Category: natural killer t cell]]
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[[Category: Natural killer t cell]]
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[[Category: t cell receptor]]
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[[Category: T cell receptor]]
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[[Category: tcr]]
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[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:52:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:19:56 2008''
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Revision as of 18:52, 3 May 2008

Image:2cde.gif

Template:STRUCTURE 2cde

STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE SPECIFIC T CELL RECEPTORS-INKT-TCR


Overview

Invariant human TCR Valpha24-Jalpha18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-alpha-glycosylceramides. We analyzed crystal structures and binding characteristics for an iNKT TCR plus two CD1d-alpha-GalCer-specific Vbeta11+ TCRs that use different TCR Valpha chains. The results were similar to those previously reported for MHC-peptide-specific TCRs, illustrating the versatility of the TCR platform. Docking TCR and CD1d-alpha-GalCer structures provided plausible insights into their interaction. The model supports a diagonal orientation of TCR on CD1d and suggests that complementarity determining region (CDR)3alpha, CDR3beta, and CDR1beta interact with ligands presented by CD1d, whereas CDR2beta binds to the CD1d alpha1 helix. This docking provides an explanation for the dominant usage of Vbeta11 and Vbeta8.2 chains by human and mouse iNKT cells, respectively, for recognition of CD1d-alpha-GalCer.

About this Structure

2CDE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors., Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY, J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:16520393 Page seeded by OCA on Sat May 3 21:52:28 2008

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