2cdn

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[[Image:2cdn.gif|left|200px]]
[[Image:2cdn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2cdn |SIZE=350|CAPTION= <scene name='initialview01'>2cdn</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2cdn", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2cdn| PDB=2cdn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdn OCA], [http://www.ebi.ac.uk/pdbsum/2cdn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cdn RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ADENYLATE KINASE COMPLEXED WITH TWO MOLECULES OF ADP AND MG'''
'''CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ADENYLATE KINASE COMPLEXED WITH TWO MOLECULES OF ADP AND MG'''
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[[Category: Haouz, A.]]
[[Category: Haouz, A.]]
[[Category: Munier-Lehmann, H.]]
[[Category: Munier-Lehmann, H.]]
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[[Category: adenylate kinase]]
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[[Category: Adenylate kinase]]
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[[Category: associative mechanism]]
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[[Category: Associative mechanism]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: nucleotide biosynthesis]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphoryl transfer]]
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[[Category: Phosphoryl transfer]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:53:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:20:02 2008''
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Revision as of 18:53, 3 May 2008

Image:2cdn.gif


PDB ID 2cdn

Drag the structure with the mouse to rotate
2cdn, resolution 1.90Å ()
Ligands: ,
Activity: Adenylate kinase, with EC number 2.7.4.3
Related: 1p4s
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ADENYLATE KINASE COMPLEXED WITH TWO MOLECULES OF ADP AND MG


Overview

The crystal structure of Mycobacterium tuberculosis adenylate kinase (MtAK) in complex with two ADP molecules and Mg2+ has been determined at 1.9 A resolution. Comparison with the solution structure of the enzyme, obtained in the absence of substrates, shows significant conformational changes of the LID and NMP-binding domains upon substrate binding. The ternary complex represents the state of the enzyme at the start of the backward reaction (ATP synthesis). The structure is consistent with a direct nucleophilic attack of a terminal oxygen from the acceptor ADP molecule on the beta-phosphate from the donor substrate, and both the geometry and the distribution of positive charge in the active site support the hypothesis of an associative mechanism for phosphoryl transfer.

About this Structure

2CDN is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Bellinzoni M, Haouz A, Grana M, Munier-Lehmann H, Shepard W, Alzari PM, Protein Sci. 2006 Jun;15(6):1489-93. Epub 2006 May 2. PMID:16672241 Page seeded by OCA on Sat May 3 21:53:23 2008

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OCA

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