CD23

From Proteopedia

Revision as of 12:46, 13 December 2017

spinqualitylabelsall models human CD23 (gold/blue) with IgE (pink/yellow) and Ca+2 ion (green) 4gko Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function CD23 is a low affinity receptor of IgE and serves as an adhesion molecule involved in cell-cell interaction[1]. Disease CD23 may be involved in the proliferation of leukemic B cells[2]. Relevance CD23 is considered important in the differentiation of chronic lymphocytic leukemia[3].

3D Structures of CD23

Updated on 13-December-2017

2h2r, 4g96, 4g9a, 4j6j, 4j6k, 4j6l, 4j6m, 4j6n, 4j6p, 4j6q – hCD23 lectin domain – human
1t8c, 1t8d – hCD23 lectin domain – NMR
2h2t, 4gi0, 4gj0, 4gjx, 4gk1 – hCD23 lectin domain (mutant)
4gko, 4ki1, 4ezm – hCD23 lectin domain + IgE-Fc

References

1. ↑ Bonnefoy JY, Lecoanet-Henchoz S, Gauchat JF, Graber P, Aubry JP, Jeannin P, Plater-Zyberk C. Structure and functions of CD23. Int Rev Immunol. 1997;16(1-2):113-28. doi: 10.3109/08830189709045705. PMID:9651788 doi:http://dx.doi.org/10.3109/08830189709045705
2. ↑ Sarfati M. CD23 and chronic lymphocytic leukemia. Blood Cells. 1993;19(3):591-6; discussion 597-9. PMID:8018941
3. ↑ DiRaimondo F, Albitar M, Huh Y, O'Brien S, Montillo M, Tedeschi A, Kantarjian H, Lerner S, Giustolisi R, Keating M. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002 Mar 15;94(6):1721-30. PMID:11920534