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5yy2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of AsqI with Zn== | |
| + | <StructureSection load='5yy2' size='340' side='right' caption='[[5yy2]], [[Resolution|resolution]] 2.91Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5yy2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YY2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yy2 OCA], [http://pdbe.org/5yy2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yy2 RCSB], [http://www.ebi.ac.uk/pdbsum/5yy2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yy2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities. Here we report in vitro and computational analyses leading to the discovery of a hemocyanin-like protein AsqI from the Aspergillus nidulans aspoquinolone biosynthetic pathway that forms viridicatins via a conversion of the cyclopenin-type 6,7-bicyclic system into the viridicatin-type 6,6-bicyclic core through elimination of carbon dioxide and methylamine through methyl isocyanate. | ||
| - | + | Enzymatic one-step ring contraction for quinolone biosynthesis.,Kishimoto S, Hara K, Hashimoto H, Hirayama Y, Champagne PA, Houk KN, Tang Y, Watanabe K Nat Commun. 2018 Jul 19;9(1):2826. doi: 10.1038/s41467-018-05221-5. PMID:30026518<ref>PMID:30026518</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5yy2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Hara, K]] | ||
| + | [[Category: Hashimoto, H]] | ||
| + | [[Category: Kishimoto, S]] | ||
| + | [[Category: Watanabe, K]] | ||
| + | [[Category: Aspoquinolone biosynthesis]] | ||
| + | [[Category: Hemocyanin like protein]] | ||
| + | [[Category: Metal binding protein]] | ||
| + | [[Category: Secondary metabolism]] | ||
Revision as of 18:39, 1 August 2018
Crystal structure of AsqI with Zn
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