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2cfq
From Proteopedia
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[[Image:2cfq.gif|left|200px]] | [[Image:2cfq.gif|left|200px]] | ||
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'''SUGAR FREE LACTOSE PERMEASE AT NEUTRAL PH''' | '''SUGAR FREE LACTOSE PERMEASE AT NEUTRAL PH''' | ||
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[[Category: Mirza, O.]] | [[Category: Mirza, O.]] | ||
[[Category: Verner, G.]] | [[Category: Verner, G.]] | ||
| - | [[Category: | + | [[Category: Formylation]] |
| - | [[Category: | + | [[Category: Lactose permease]] |
| - | [[Category: | + | [[Category: Lactose/h+ symport]] |
| - | [[Category: | + | [[Category: Sugar transport]] |
| - | [[Category: | + | [[Category: Transmembrane]] |
| - | [[Category: | + | [[Category: Transport mechanism]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:01:57 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 19:01, 3 May 2008
SUGAR FREE LACTOSE PERMEASE AT NEUTRAL PH
Overview
Cation-coupled active transport is an essential cellular process found ubiquitously in all living organisms. Here, we present two novel ligand-free X-ray structures of the lactose permease (LacY) of Escherichia coli determined at acidic and neutral pH, and propose a model for the mechanism of coupling between lactose and H+ translocation. No sugar-binding site is observed in the absence of ligand, and deprotonation of the key residue Glu269 is associated with ligand binding. Thus, substrate induces formation of the sugar-binding site, as well as the initial step in H+ transduction.
About this Structure
2CFQ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY., Mirza O, Guan L, Verner G, Iwata S, Kaback HR, EMBO J. 2006 Mar 22;25(6):1177-83. Epub 2006 Mar 9. PMID:16525509 Page seeded by OCA on Sat May 3 22:01:57 2008
