2cg9

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[[Image:2cg9.gif|left|200px]]
[[Image:2cg9.gif|left|200px]]
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{{Structure
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|PDB= 2cg9 |SIZE=350|CAPTION= <scene name='initialview01'>2cg9</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2cg9", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Atp+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>
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{{STRUCTURE_2cg9| PDB=2cg9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg9 OCA], [http://www.ebi.ac.uk/pdbsum/2cg9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cg9 RCSB]</span>
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'''CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX'''
'''CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX'''
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[[Category: Prodromou, C.]]
[[Category: Prodromou, C.]]
[[Category: Roe, S M.]]
[[Category: Roe, S M.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: chaperone complex]]
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[[Category: Chaperone complex]]
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[[Category: co-chaperone]]
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[[Category: Co-chaperone]]
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[[Category: heat shock]]
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[[Category: Heat shock]]
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[[Category: heat shock protein]]
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[[Category: Heat shock protein]]
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[[Category: hsp90]]
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[[Category: Hsp90]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:04:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:21:03 2008''
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Revision as of 19:04, 3 May 2008

Image:2cg9.gif


PDB ID 2cg9

Drag the structure with the mouse to rotate
2cg9, resolution 3.10Å ()
Ligands:
Related: 1a4h, 1ah6, 1ah8, 1am1, 1amw, 1bgq, 1hk7, 1us7, 1usu, 1usv, 2akp, 2brc, 2bre, 2cge
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX


Overview

Hsp90 (heat shock protein of 90 kDa) is a ubiquitous molecular chaperone responsible for the assembly and regulation of many eukaryotic signalling systems and is an emerging target for rational chemotherapy of many cancers. Although the structures of isolated domains of Hsp90 have been determined, the arrangement and ATP-dependent dynamics of these in the full Hsp90 dimer have been elusive and contentious. Here we present the crystal structure of full-length yeast Hsp90 in complex with an ATP analogue and the co-chaperone p23/Sba1. The structure reveals the complex architecture of the 'closed' state of the Hsp90 chaperone, the extensive interactions between domains and between protein chains, the detailed conformational changes in the amino-terminal domain that accompany ATP binding, and the structural basis for stabilization of the closed state by p23/Sba1. Contrary to expectations, the closed Hsp90 would not enclose its client proteins but provides a bipartite binding surface whose formation and disruption are coupled to the chaperone ATPase cycle.

About this Structure

2CG9 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex., Ali MM, Roe SM, Vaughan CK, Meyer P, Panaretou B, Piper PW, Prodromou C, Pearl LH, Nature. 2006 Apr 20;440(7087):1013-7. PMID:16625188 Page seeded by OCA on Sat May 3 22:04:28 2008

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