6f9i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide from calsyntenin-1== | |
| - | + | <StructureSection load='6f9i' size='340' side='right' caption='[[6f9i]], [[Resolution|resolution]] 3.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f9i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F9I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ejn|6ejn]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f9i OCA], [http://pdbe.org/6f9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f9i RCSB], [http://www.ebi.ac.uk/pdbsum/6f9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f9i ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSTN1_MOUSE CSTN1_MOUSE]] Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.<ref>PMID:12972431</ref> <ref>PMID:17332754</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cockburn, J J.B]] | ||
| + | [[Category: Activation]] | ||
| + | [[Category: Cargo]] | ||
| + | [[Category: Kinesin]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Transport]] | ||
Revision as of 10:11, 5 September 2018
Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide from calsyntenin-1
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