This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6f9i
From Proteopedia
(Difference between revisions)
m (Protected "6f9i" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide from calsyntenin-1== | |
| - | + | <StructureSection load='6f9i' size='340' side='right' caption='[[6f9i]], [[Resolution|resolution]] 3.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f9i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F9I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ejn|6ejn]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f9i OCA], [http://pdbe.org/6f9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f9i RCSB], [http://www.ebi.ac.uk/pdbsum/6f9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f9i ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSTN1_MOUSE CSTN1_MOUSE]] Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals.<ref>PMID:12972431</ref> <ref>PMID:17332754</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cockburn, J J.B]] | ||
| + | [[Category: Activation]] | ||
| + | [[Category: Cargo]] | ||
| + | [[Category: Kinesin]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Transport]] | ||
Revision as of 10:11, 5 September 2018
Crystal structure of KLC2 bound to the second tryptophan-acidic motif peptide from calsyntenin-1
| |||||||||||
