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2chd
From Proteopedia
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[[Image:2chd.gif|left|200px]] | [[Image:2chd.gif|left|200px]] | ||
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'''CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A''' | '''CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A''' | ||
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[[Category: Montaville, P.]] | [[Category: Montaville, P.]] | ||
[[Category: Sheldrick, G M.]] | [[Category: Sheldrick, G M.]] | ||
| - | [[Category: | + | [[Category: C2 domain]] |
| - | [[Category: | + | [[Category: C2a]] |
| - | [[Category: | + | [[Category: Calcium binding]] |
| - | [[Category: | + | [[Category: Metal-binding]] |
| - | [[Category: | + | [[Category: Protein transport]] |
| - | [[Category: | + | [[Category: Rabphilin-3a]] |
| - | [[Category: | + | [[Category: Synapse]] |
| - | [[Category: | + | [[Category: Synaptic exocytosis]] |
| - | [[Category: | + | [[Category: Transport]] |
| - | [[Category: | + | [[Category: Zinc]] |
| - | [[Category: | + | [[Category: Zinc-finger]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:08:41 2008'' | |
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Revision as of 19:08, 3 May 2008
CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A
Overview
Rabphilin-3A is a neuronal protein containing a C2-domain tandem. To date, only the structure of the C2B domain has been solved. The crystal structure of the Ca2+-free C2A domain has been solved by molecular replacement and refined to 1.92 A resolution. It adopts the classical C2-domain fold consisting of an eight-stranded antiparallel beta-sandwich with type I topology. In agreement with its Ca2+-dependent negatively charged membrane-binding properties, this C2 domain contains all the conserved acidic residues responsible for calcium binding. However, the replacement of a conserved aspartic acid residue by glutamic acid allows formation of an additional strong hydrogen bond, resulting in increased rigidity of calcium-binding loop 1. The electrostatic surface of the C2A domain consists of a large positively charged belt surrounded by two negatively charged patches located at both tips of the domain. In comparison, the structurally very similar C2A domain of synaptotagmin I has a highly acidic electrostatic surface, suggesting completely unrelated functions for these two C2A domains.
About this Structure
2CHD is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure of the C2A domain of rabphilin-3A., Biadene M, Montaville P, Sheldrick GM, Becker S, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):793-9. Epub 2006, Jun 20. PMID:16790935 Page seeded by OCA on Sat May 3 22:08:41 2008
