2ci3

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[[Image:2ci3.gif|left|200px]]
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{{Structure
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dimethylargininase Dimethylargininase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18] </span>
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{{STRUCTURE_2ci3| PDB=2ci3 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ci3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ci3 OCA], [http://www.ebi.ac.uk/pdbsum/2ci3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ci3 RCSB]</span>
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'''CRYSTAL STRUCTURE OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE CRYSTAL FORM I'''
'''CRYSTAL STRUCTURE OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE CRYSTAL FORM I'''
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[[Category: Grutter, M G.]]
[[Category: Grutter, M G.]]
[[Category: Vasak, M.]]
[[Category: Vasak, M.]]
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[[Category: adma]]
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[[Category: Adma]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: mma]]
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[[Category: Mma]]
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[[Category: no]]
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[[Category: No]]
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[[Category: nos regulation]]
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[[Category: Nos regulation]]
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[[Category: s-nitrosylation]]
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[[Category: S-nitrosylation]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:11:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:21:47 2008''
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Revision as of 19:11, 3 May 2008

Image:2ci3.gif

Template:STRUCTURE 2ci3

CRYSTAL STRUCTURE OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE CRYSTAL FORM I


Overview

Dimethylarginine dimethylaminohydrolase (DDAH) is involved in the regulation of nitric oxide synthase (NOS) by metabolizing the free endogenous arginine derivatives N(omega)-methyl-L-arginine (MMA) and N(omega),N(omega)-dimethyl-L-arginine (ADMA), which are competitive inhibitors of NOS. Here, we present high-resolution crystal structures of DDAH isoform 1 (DDAH-1) isolated from bovine brain in complex with different inhibitors, including S-nitroso-L-homocysteine and Zn2+, a regulator of this mammalian enzyme. The structure of DDAH-1 consists of a propeller-like fold similar to other arginine-modifying enzymes and a flexible loop, which adopts different conformations and acts as a lid at the entrance of the active site. The orientation and interaction mode of inhibitors in the active site give insight into the regulation and the molecular mechanism of the enzyme. The presented structures provide a basis for the structure-based development of specific DDAH-1 inhibitors that might be useful in the therapeutic treatment of NOS dysfunction-related diseases.

About this Structure

2CI3 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of the mammalian NOS regulator dimethylarginine dimethylaminohydrolase: A basis for the design of specific inhibitors., Frey D, Braun O, Briand C, Vasak M, Grutter MG, Structure. 2006 May;14(5):901-11. PMID:16698551 Page seeded by OCA on Sat May 3 22:11:58 2008

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