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2cik

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[[Image:2cik.jpg|left|200px]]
[[Image:2cik.jpg|left|200px]]
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{{Structure
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|PDB= 2cik |SIZE=350|CAPTION= <scene name='initialview01'>2cik</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_2cik", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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{{STRUCTURE_2cik| PDB=2cik | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cik OCA], [http://www.ebi.ac.uk/pdbsum/2cik PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cik RCSB]</span>
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'''INSIGHTS INTO CROSSREACTIVITY IN HUMAN ALLORECOGNITION: THE STRUCTURE OF HLA-B35011 PRESENTING AN EPITOPE DERIVED FROM CYTOCHROME P450.'''
'''INSIGHTS INTO CROSSREACTIVITY IN HUMAN ALLORECOGNITION: THE STRUCTURE OF HLA-B35011 PRESENTING AN EPITOPE DERIVED FROM CYTOCHROME P450.'''
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[[Category: Jones, E Y.]]
[[Category: Jones, E Y.]]
[[Category: Peterson, N A.]]
[[Category: Peterson, N A.]]
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[[Category: allo-ligand]]
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[[Category: Allo-ligand]]
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[[Category: antigen/peptide complex]]
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[[Category: Antigen/peptide complex]]
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[[Category: ebv]]
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[[Category: Ebv]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hla]]
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[[Category: Hla]]
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[[Category: hla-b3501]]
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[[Category: Hla-b3501]]
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[[Category: human]]
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[[Category: Human]]
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[[Category: immune response]]
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[[Category: Immune response]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: major histocompatibility antigen]]
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[[Category: Major histocompatibility antigen]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: mhc i]]
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[[Category: Mhc i]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: pyrrolidone carboxylic acid]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:13:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:22:01 2008''
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Revision as of 19:13, 3 May 2008

Image:2cik.jpg

Template:STRUCTURE 2cik

INSIGHTS INTO CROSSREACTIVITY IN HUMAN ALLORECOGNITION: THE STRUCTURE OF HLA-B35011 PRESENTING AN EPITOPE DERIVED FROM CYTOCHROME P450.


Overview

Virus-specific T cell populations have been implicated in allo-recognition. The subdominant T cell receptor JL12 recognizes both HLA-B*0801 presenting the Epstein-Barr virus-derived peptide FLRGRAYGL and also HLA-B*3501 presenting the cytochrome p450 self peptide KPIVVLHGY. This cross-reactivity could promote the rejection of HLA-B*3501-positive cells in Epstein-Barr virus-exposed HLA-B*0801 recipients. LC13, the dominant TCR against the HLA-B*0801:FLRGRAYGL complex, fails to recognize HLA-B*3501:KPIVVLHGY. We report the 1.75-Angstrom resolution crystal structure of the human allo-ligand HLA-B*3501:KPIVVLHGY. Similarities between this structure and that of HLA-B*0801:FLRGRAYGL may facilitate cross-recognition by JL12. Moreover, the elevated peptide position in HLA-B*3501:KPIVVLHGY would provide steric hindrance to LC13, preventing it from interacting in the manner in which it interacts with HLA-B*0801:FLRGRAYGL. These findings are relevant to understanding the basis of T cell cross-reactivity in allo-recognition, optimal transplant donor-recipient matching and developing specific molecular inhibitors of allo-recognition.

About this Structure

2CIK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the human allo-ligand HLA-B*3501 in complex with a cytochrome p450 peptide: steric hindrance influences TCR allo-recognition., Hourigan CS, Harkiolaki M, Peterson NA, Bell JI, Jones EY, O'Callaghan CA, Eur J Immunol. 2006 Dec;36(12):3288-93. PMID:17109469 Page seeded by OCA on Sat May 3 22:13:32 2008

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