2cjc

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[[Image:2cjc.gif|left|200px]]
[[Image:2cjc.gif|left|200px]]
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{{Structure
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|PDB= 2cjc |SIZE=350|CAPTION= <scene name='initialview01'>2cjc</scene>, resolution 1.85&Aring;
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The line below this paragraph, containing "STRUCTURE_2cjc", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_2cjc| PDB=2cjc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjc OCA], [http://www.ebi.ac.uk/pdbsum/2cjc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cjc RCSB]</span>
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'''COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS'''
'''COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS'''
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[[Category: Seiler, F.]]
[[Category: Seiler, F.]]
[[Category: Zeth, K.]]
[[Category: Zeth, K.]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:16:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:22:17 2008''
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Revision as of 19:16, 3 May 2008

Image:2cjc.gif

Template:STRUCTURE 2cjc

COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS


Overview

Both extensive theoretical calculations and experimental data obtained during several decades leave little doubt that flavin adenine dinucleotide (FAD) exists in an open as well as in a closed conformation in aqueous solution. However, the knowledge about the intramolecularly stacked complex of FAD is constructed on indirect methods while direct structural evidence is lacking. Recently, dodecin was reported as an unspecific flavin binding protein which exhibits the unique binding mode of incorporating stacked dimers of flavins into a single binding pocket. Here, we show that FAD is not bound in this manner, but in monomers of intramolecularly stacked conformation. As resulting from the dodecin ligand binding characteristic, this FAD stacked conformation suggests to be directly sequestered from the aqueous solution and thus to be the first X-ray structural view on a FAD solution-stacked form. Moreover, in extraordinary FAD binding, dodecin serves as a model for studying bound monomeric (FAD) versus bound dimeric (e.g. riboflavin) flavin properties.

About this Structure

2CJC is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Dodecin sequesters FAD in closed conformation from the aqueous solution., Grininger M, Seiler F, Zeth K, Oesterhelt D, J Mol Biol. 2006 Dec 8;364(4):561-6. Epub 2006 Sep 5. PMID:17027852 Page seeded by OCA on Sat May 3 22:16:53 2008

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