2cky

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[[Image:2cky.gif|left|200px]]
[[Image:2cky.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2cky |SIZE=350|CAPTION= <scene name='initialview01'>2cky</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2cky", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Tpp+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2cky| PDB=2cky | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cky OCA], [http://www.ebi.ac.uk/pdbsum/2cky PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cky RCSB]</span>
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'''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''
'''Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand'''
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==About this Structure==
==About this Structure==
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2CKY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA].
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2CKY is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKY OCA].
==Reference==
==Reference==
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[[Category: Leibundgut, M.]]
[[Category: Leibundgut, M.]]
[[Category: Thore, S.]]
[[Category: Thore, S.]]
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[[Category: nucleic acid]]
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[[Category: Nucleic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:23:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:22:56 2008''
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Revision as of 19:23, 3 May 2008

Image:2cky.gif

Template:STRUCTURE 2cky

Structure of the arabidopsis thaliana thiamine pyrophosphate riboswitch with its regulatory ligand


Overview

Riboswitches are untranslated regions of messenger RNA, which adopt alternate structures depending on the binding of specific metabolites. Such conformational switching regulates the expression of proteins involved in the biosynthesis of riboswitch substrates. Here, we present the 2.9 angstrom-resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate (TPP)-specific riboswitch in complex with its natural ligand. The riboswitch specifically recognizes the TPP via conserved residues located within two highly distorted parallel "sensor" helices. The structure provides the basis for understanding the reorganization of the riboswitch fold upon TPP binding and explains the mechanism of resistance to the antibiotic pyrithiamine.

About this Structure

2CKY is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand., Thore S, Leibundgut M, Ban N, Science. 2006 May 26;312(5777):1208-11. Epub 2006 May 4. PMID:16675665 Page seeded by OCA on Sat May 3 22:23:22 2008

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