2cm0

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[[Image:2cm0.gif|left|200px]]
[[Image:2cm0.gif|left|200px]]
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{{Structure
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|PDB= 2cm0 |SIZE=350|CAPTION= <scene name='initialview01'>2cm0</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_2cm0", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Bme+Binding+Site+For+Chain+A'>AC1</scene>
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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{{STRUCTURE_2cm0| PDB=2cm0 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm0 OCA], [http://www.ebi.ac.uk/pdbsum/2cm0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cm0 RCSB]</span>
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'''THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.'''
'''THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.'''
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[[Category: Buchberger, A.]]
[[Category: Buchberger, A.]]
[[Category: Bycroft, M.]]
[[Category: Bycroft, M.]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: pug domain]]
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[[Category: Pug domain]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:28:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:21 2008''
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Revision as of 19:28, 3 May 2008

Image:2cm0.gif

Template:STRUCTURE 2cm0

THE PUB DOMAIN FUNCTIONS AS A P97 BINDING MODULE IN HUMAN PEPTIDE N-GLYCANASE.


Overview

The AAA ATPase p97 is a ubiquitin-selective molecular machine involved in multiple cellular processes, including protein degradation through the ubiquitin-proteasome system and homotypic membrane fusion. Specific p97 functions are mediated by a variety of cofactors, among them peptide N-glycanase, an enzyme that removes glycans from misfolded glycoproteins. Here we report the three-dimensional structure of the aminoterminal PUB domain of human peptide N-glycanase. We demonstrate that the PUB domain is a novel p97 binding module interacting with the D1 and/or D2 ATPase domains of p97 and identify an evolutionary conserved surface patch required for p97 binding. Furthermore, we show that the PUB and UBX domains do not bind to p97 in a mutually exclusive manner. Our results suggest that PUB domain-containing proteins constitute a widespread family of diverse p97 cofactors.

About this Structure

2CM0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The PUB domain functions as a p97 binding module in human peptide N-glycanase., Allen MD, Buchberger A, Bycroft M, J Biol Chem. 2006 Sep 1;281(35):25502-8. Epub 2006 Jun 28. PMID:16807242 Page seeded by OCA on Sat May 3 22:28:10 2008

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