This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5yms
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis of glycan specificity and identification of a novel glycan binding cavity in human P[19] rotavirus== | |
| - | + | <StructureSection load='5yms' size='340' side='right' caption='[[5yms]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yms]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YMS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yms OCA], [http://pdbe.org/5yms PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yms RCSB], [http://www.ebi.ac.uk/pdbsum/5yms PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yms ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9Q2P6_9REOV Q9Q2P6_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dandi, L]] | ||
| + | [[Category: Duan, Z]] | ||
| + | [[Category: Sun, X]] | ||
| + | [[Category: Mucin core2core 2]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Vp8*]] | ||
Revision as of 08:05, 2 May 2018
Structural basis of glycan specificity and identification of a novel glycan binding cavity in human P[19] rotavirus
| |||||||||||
Categories: Dandi, L | Duan, Z | Sun, X | Mucin core2core 2 | Viral protein | Vp8*
