6bnm
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the P-Rex2 PH domain== | |
| - | + | <StructureSection load='6bnm' size='340' side='right'caption='[[6bnm]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BNM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PREX2, DEPDC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnm OCA], [http://pdbe.org/6bnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bnm RCSB], [http://www.ebi.ac.uk/pdbsum/6bnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PREX2_HUMAN PREX2_HUMAN]] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.<ref>PMID:15304342</ref> <ref>PMID:15304343</ref> <ref>PMID:15897194</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cash, J N]] | ||
| + | [[Category: Sharma, P V]] | ||
| + | [[Category: Tesmer, J J.G]] | ||
| + | [[Category: Beta sandwich]] | ||
| + | [[Category: Lipid binding protein]] | ||
| + | [[Category: Phosphatidylinositol-binding]] | ||
| + | [[Category: Pleckstrin homology domain]] | ||
Revision as of 22:59, 5 June 2019
Crystal Structure of the P-Rex2 PH domain
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