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5whr

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Current revision (08:52, 30 September 2020) (edit) (undo)
 
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==Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate.==
==Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate.==
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<StructureSection load='5whr' size='340' side='right' caption='[[5whr]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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<StructureSection load='5whr' size='340' side='right'caption='[[5whr]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5whr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WHR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5whr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WHR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WHR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AOJ:(3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione'>AOJ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOJ:(3R)-3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione'>AOJ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase Indoleamine 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.52 1.13.11.52] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase Indoleamine 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.52 1.13.11.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5whr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5whr OCA], [http://pdbe.org/5whr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5whr RCSB], [http://www.ebi.ac.uk/pdbsum/5whr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5whr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5whr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5whr OCA], [http://pdbe.org/5whr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5whr RCSB], [http://www.ebi.ac.uk/pdbsum/5whr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5whr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</div>
</div>
<div class="pdbe-citations 5whr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5whr" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Indoleamine 2,3-dioxygenase]]
[[Category: Indoleamine 2,3-dioxygenase]]
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[[Category: Large Structures]]
[[Category: Feng, J L]]
[[Category: Feng, J L]]
[[Category: Greasley, S E]]
[[Category: Greasley, S E]]

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Discovery of a novel and selective IDO-1 inhibitor PF-06840003 and its characterization as a potential clinical candidate.

PDB ID 5whr

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