Tdp-43
From Proteopedia
(Difference between revisions)
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== Disease == | == Disease == | ||
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| + | Tdp-43 mutations were found ion familial and sporadic ALS patients<ref>PMID:18309045</ref>. Phosphorylated Tdp-43 is deposited as cytoplasmic and intranuclear inclusions in brains of patients with frontotemporal lobar degeneration and ALS<ref>PMID:18546284</ref>. | ||
== Relevance == | == Relevance == | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. | ||
</StructureSection> | </StructureSection> | ||
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| + | == 3D Structures of Tdp-43 == | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | [[2cqg]] – hTDP-43 RRM1 domain – human - NMR <br /> | ||
| + | [[1wf0]] – hTDP-43 RRM2 domain - NMR <br /> | ||
| + | [[5mrg]], [[2n4p]], [[5x4f]] – hTDP-43 N-terminal domain - NMR <br /> | ||
| + | [[5mdi]] – hTDP-43 N-terminal domain <br /> | ||
| + | [[2n2c]], [[2n3x]] – hTDP-43 prion-like helix - NMR <br /> | ||
| + | [[2n4g]], [[2n4h]] – hTDP-43 prion-like helix (mutant) - NMR <br /> | ||
| + | [[4y0f]], [[4iuf]] – hTDP-43 RRM1 domain + DNA <br /> | ||
| + | [[4y00]] – hTDP-43 RRM1 domain (mutant) + DNA <br /> | ||
| + | [[4bs2]] – hTDP-43 RRM1+RRM2 domains + RNA - NMR<br /> | ||
| + | [[3d2w]] – TDP-43 RRM2 domain + DNA - mouse<br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 08:11, 2 January 2018
TDP-43 helical stabilizers
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3D Structures of Tdp-43
Updated on 02-January-2018
2cqg – hTDP-43 RRM1 domain – human - NMR
1wf0 – hTDP-43 RRM2 domain - NMR
5mrg, 2n4p, 5x4f – hTDP-43 N-terminal domain - NMR
5mdi – hTDP-43 N-terminal domain
2n2c, 2n3x – hTDP-43 prion-like helix - NMR
2n4g, 2n4h – hTDP-43 prion-like helix (mutant) - NMR
4y0f, 4iuf – hTDP-43 RRM1 domain + DNA
4y00 – hTDP-43 RRM1 domain (mutant) + DNA
4bs2 – hTDP-43 RRM1+RRM2 domains + RNA - NMR
3d2w – TDP-43 RRM2 domain + DNA - mouse
References
- ↑ Buratti E, Baralle FE. Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease. Front Biosci. 2008 Jan 1;13:867-78. PMID:17981595
- ↑ Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S, Durnall JC, Williams KL, Buratti E, Baralle F, de Belleroche J, Mitchell JD, Leigh PN, Al-Chalabi A, Miller CC, Nicholson G, Shaw CE. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science. 2008 Mar 21;319(5870):1668-72. doi: 10.1126/science.1154584. Epub 2008, Feb 28. PMID:18309045 doi:10.1126/science.1154584
- ↑ Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama H. Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann Neurol. 2008 Jul;64(1):60-70. doi: 10.1002/ana.21425. PMID:18546284 doi:http://dx.doi.org/10.1002/ana.21425
