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5z1w
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of polycystic kidney disease-like channel PKD2L1== | |
| - | + | <StructureSection load='5z1w' size='340' side='right' caption='[[5z1w]], [[Resolution|resolution]] 3.38Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5z1w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z1W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z1w OCA], [http://pdbe.org/5z1w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z1w RCSB], [http://www.ebi.ac.uk/pdbsum/5z1w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z1w ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PK2L1_MOUSE PK2L1_MOUSE]] Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. May play a role in the perception of carbonation taste.<ref>PMID:15548533</ref> <ref>PMID:16891422</ref> <ref>PMID:16929298</ref> <ref>PMID:19833970</ref> <ref>PMID:21098668</ref> <ref>PMID:21625513</ref> <ref>PMID:24336288</ref> <ref>PMID:24336289</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Zhang, Y Q]] | ||
| + | [[Category: Channel]] | ||
| + | [[Category: Cryo-em]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 06:35, 28 March 2018
Cryo-EM structure of polycystic kidney disease-like channel PKD2L1
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