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6fdi

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m (Protected "6fdi" [edit=sysop:move=sysop])
Current revision (07:13, 10 April 2019) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6fdi is ON HOLD until Paper Publication
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==Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-226==
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<StructureSection load='6fdi' size='340' side='right'caption='[[6fdi]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Singh, A.K., Brown, D.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6fdi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FDI FirstGlance]. <br>
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Description: Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-226
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D5T:1-[2-[4-[(4~{a}~{S},8~{a}~{R})-4-(3,4-dimethoxyphenyl)-1-oxidanylidene-4~{a},5,8,8~{a}-tetrahydrophthalazin-2-yl]piperidin-1-yl]-2-oxidanylidene-ethyl]-4,4-dimethyl-piperidine-2,6-dione'>D5T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
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[[Category: Brown, D.G]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fdi OCA], [http://pdbe.org/6fdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fdi RCSB], [http://www.ebi.ac.uk/pdbsum/6fdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fdi ProSAT]</span></td></tr>
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[[Category: Singh, A.K]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
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[[Category: Large Structures]]
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[[Category: Brown, D G]]
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[[Category: Singh, A K]]
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[[Category: Alternative splicing]]
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[[Category: Camp hydrolysis]]
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[[Category: Hydrolase]]
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[[Category: Phosphodiesterase]]

Current revision

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-226

PDB ID 6fdi

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