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5mih

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Current revision (18:44, 1 November 2023) (edit) (undo)
 
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==Crystal structure of the lectin LecA from Pseudomonas aeruginosa in complex with a phenyl-epoxy-galactopyranoside==
==Crystal structure of the lectin LecA from Pseudomonas aeruginosa in complex with a phenyl-epoxy-galactopyranoside==
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<StructureSection load='5mih' size='340' side='right' caption='[[5mih]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5mih' size='340' side='right'caption='[[5mih]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mih]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MIH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mih]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MIH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7NU:Phenyl+6,7-dideoxy-6,7-epoxy-beta-D-galacto-heptopyranoside(6D)'>7NU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ETE:2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>ETE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lecA, pa1L, PA2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7NU:phenyl+6,7-anhydro-D-glycero-beta-D-galacto-heptopyranoside'>7NU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ETE:2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>ETE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mih OCA], [http://pdbe.org/5mih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mih RCSB], [http://www.ebi.ac.uk/pdbsum/5mih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mih ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mih OCA], [https://pdbe.org/5mih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mih RCSB], [https://www.ebi.ac.uk/pdbsum/5mih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mih ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
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[https://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mih" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mih" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Galactose-binding lectin|Galactose-binding lectin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pseae]]
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[[Category: Large Structures]]
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[[Category: Hauk, D]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Hofmann, M]]
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[[Category: Hauk D]]
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[[Category: Imberty, A]]
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[[Category: Hofmann M]]
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[[Category: Joachim, I]]
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[[Category: Imberty A]]
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[[Category: Muller, R]]
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[[Category: Joachim I]]
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[[Category: Sommer, R]]
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[[Category: Muller R]]
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[[Category: Titz, A]]
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[[Category: Sommer R]]
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[[Category: Varrot, A]]
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[[Category: Titz A]]
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[[Category: Wagner, S]]
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[[Category: Varrot A]]
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[[Category: Covalent lectin inhibition]]
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[[Category: Wagner S]]
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[[Category: Galactose binding protein]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of the lectin LecA from Pseudomonas aeruginosa in complex with a phenyl-epoxy-galactopyranoside

PDB ID 5mih

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