Topoisomerase

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<StructureSection load='2h7f' size='400' side='right' caption='Topoisomerase I complex with DNA and phosphotyrosine (PDB entry [[2h7f]])' scene=''>
+
<StructureSection load='2h7f' size='350' side='right' caption='Topoisomerase I complex with DNA and phosphotyrosine (PDB entry [[2h7f]])' scene=''>
__TOC__
__TOC__
==Function==
==Function==
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*Topoisomerase I (ATP-independent)
*Topoisomerase I (ATP-independent)
-
**[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – ''Smallpox virus''<br />
+
**[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – Smallpox virus<br />
**[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br />
**[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br />
**[[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br />
**[[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br />
Line 668: Line 668:
**[[1ecl]], [[1cy4]] - EcTOPI N-terminal<br />
**[[1ecl]], [[1cy4]] - EcTOPI N-terminal<br />
**[[3pwt]] - EcTOPIA N-terminal (mutant)<br />
**[[3pwt]] - EcTOPIA N-terminal (mutant)<br />
-
**[[1a41]] – VvTOPI C-terminal – ''Vaccinia virus''<br />
+
**[[1a41]] – VvTOPI C-terminal – Vaccinia virus<br />
**[[1vcc]] – VvTOPI N-terminal<br />
**[[1vcc]] – VvTOPI N-terminal<br />
**[[1ois]] – yTOPI N-terminal - yeast<br />
**[[1ois]] – yTOPI N-terminal - yeast<br />
-
**[[5d5h]] - TOPI – ''Mycobacterium tuberculosis''<br />
+
**[[5d5h]], [[5uji]], [[5ujy]] - MtTOPI – ''Mycobacterium tuberculosis''<br />
 +
**[[6cq2]], [[6cqi]] – MtTOPI + DNA<br />
*Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]]
*Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]]
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*Topoisomerase IV
*Topoisomerase IV
-
**[[3fv5]] – EcTOPIV subunit B <br />
 
-
**[[4hz0]] - EcTOPIV subunit B + inhibitor<br />
 
**[[1zvt]], [[1zvu]] - EcTOPIV subunit A<br />
**[[1zvt]], [[1zvu]] - EcTOPIV subunit A<br />
-
**[[4mn4]] - EcTOPIV subunit A + MukB<br />
+
**[[3fv5]], [[1s14]] – EcTOPIV subunit B <br />
-
**[[1s14]] – EcTOPIV ParE<br />
+
**[[6bq9]] - EcTOPIV subunit A N-terminal - ''Pseudomonas putida''<br />
-
**[[1s16]] - EcTOPIV ParE+ADPNP<br />
+
-
**[[3ksb]], [[4i3h]] - SpTOPIV subunit A+B+DNA<br />
+
-
**[[4juo]], [[4koe]], [[3rae]], [[3rad]], [[3k9f]] - SpTOPIV subunit A+B+DNA + floxacin derivative<br />
+
-
**[[4kpe]], [[3foe]], [[3fof]], [[4kpf]] - SpTOPIV subunit A+B (mutant) +DNA + quinolone derivative<br />
+
-
**[[3raf]], [[3ltn]] - SpTOPIV subunit A+B+DNA+quinazoline derivative<br />
+
-
**[[4z53]], [[4z4q]], [[4z3o]] - SpTOPIV subunit A+B+DNA+ drug<br />
+
**[[2nov]] - SpTOPIV subunit A<br />
**[[2nov]] - SpTOPIV subunit A<br />
-
**[[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]], [[5boc]], [[5bod]] - SpTOPIV subunit B + inhibitor<br />
 
-
**[[5j5q]], [[5j5p]] - SpTOPIV subunit B + DNA<br />
 
**[[2inr]] - SaTOPIV subunit A – ''Staphylococcus aureus''<br />
**[[2inr]] - SaTOPIV subunit A – ''Staphylococcus aureus''<br />
-
**[[4url]], [[4urn]] - SaTOPIV subunit B N terminal + antibiotic<br />
 
**[[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus''<br />
**[[1wp5]] – TOPIV C-terminal – ''Geobacillus stearothermophilus''<br />
**[[2xkj]] – AbTOPIV pare+parc subunits – ''Acinetobacter baumannii''<br />
**[[2xkj]] – AbTOPIV pare+parc subunits – ''Acinetobacter baumannii''<br />
-
**[[2xkk]] - AbTOPIV pare+parc subunits+DNA + moxifloxacin<br />
 
**[[3lnu]], [[3lps]] - TOPIV subunit B N-terminal – ''Xanthomonas oryzae''<br />
**[[3lnu]], [[3lps]] - TOPIV subunit B N-terminal – ''Xanthomonas oryzae''<br />
 +
 +
*Topoisomerase IV complexes
 +
 +
**[[4hz0]] - EcTOPIV subunit B + inhibitor<br />
 +
**[[4mn4]] - EcTOPIV subunit A + MukB<br />
 +
**[[1s16]] - EcTOPIV subunit B + ADPNP<br />
 +
**[[3ksb]], [[4i3h]] - SpTOPIV subunit A+B + DNA<br />
 +
**[[4juo]], [[4koe]], [[3rae]], [[3rad]], [[3k9f]], [[4z53]], [[4z4q]], [[4z3o]] - SpTOPIV subunit A+B + DNA + drug<br />
 +
**[[4kpe]], [[3foe]], [[3fof]], [[4kpf]] - SpTOPIV subunit A+B (mutant) + DNA + quinolone derivative<br />
 +
**[[3raf]], [[3ltn]] - SpTOPIV subunit A+B + DNA + quinazoline derivative<br />
 +
**[[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]], [[5boc]], [[5bod]], [[5yig]] - SpTOPIV subunit B + inhibitor<br />
 +
**[[5j5q]], [[5j5p]] - SpTOPIV subunit B + DNA<br />
 +
**[[4url]], [[4urn]] - SaTOPIV subunit B N terminal + antibiotic<br />
 +
**[[2xkk]] - AbTOPIV pare+parc subunits + DNA + moxifloxacin<br />
**[[4hxz]], [[4hy1]] - hTOPIV subunit B + inhibitor<br />
**[[4hxz]], [[4hy1]] - hTOPIV subunit B + inhibitor<br />
**[[4hym]], [[4kqv]] - TOPIV subunit B + inhibitor – ''Francisella tularensis''<br />
**[[4hym]], [[4kqv]] - TOPIV subunit B + inhibitor – ''Francisella tularensis''<br />

Revision as of 17:47, 26 September 2018

Topoisomerase I complex with DNA and phosphotyrosine (PDB entry 2h7f)

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GO Annotations

Database ID Symbol Qualifier GO Identifier GO Term Name Aspect Evidence Reference With Taxon Date Assigned by Product Form ID
UniProtKB P14294 topB GO:0006259 DNA metabolic process P IEA InterPro2GO InterPro:IPR006154 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006265 DNA topological change P IEA InterPro2GO InterPro:IPR000380 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006265 DNA topological change P IEA InterPro2GO InterPro:IPR003601 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006265 DNA topological change P IEA InterPro2GO InterPro:IPR003602 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006265 DNA topological change P IEA InterPro2GO InterPro:IPR005738 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006265 DNA topological change P IEA InterPro2GO InterPro:IPR013497 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006265 DNA topological change P IEA InterPro2GO InterPro:IPR013824 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006265 DNA topological change P IEA InterPro2GO InterPro:IPR013825 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006268 DNA unwinding involved in replication P IEA InterPro2GO InterPro:IPR013824 83333 20101127 InterPro
UniProtKB P14294 topB GO:0006268 DNA unwinding involved in replication P IEA InterPro2GO InterPro:IPR013825 83333 20101127 InterPro
UniProtKB P14294 topB GO:0000166 nucleotide binding F IEA Swiss-Prot Keywords2GO SP_KW:KW-0547 83333 20101127 UniProtKB
UniProtKB P14294 topB GO:0003676 nucleic acid binding F IEA InterPro2GO InterPro:IPR006154 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA InterPro2GO InterPro:IPR000380 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA InterPro2GO InterPro:IPR003601 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA InterPro2GO InterPro:IPR003602 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA InterPro2GO InterPro:IPR005738 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA InterPro2GO InterPro:IPR013497 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA InterPro2GO InterPro:IPR013824 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA InterPro2GO InterPro:IPR013825 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003677 DNA binding F IEA Swiss-Prot Keywords2GO SP_KW:KW-0238 83333 20101127 UniProtKB
UniProtKB P14294 topB GO:0003916 DNA topoisomerase activity F IEA InterPro2GO InterPro:IPR003601 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003916 DNA topoisomerase activity F IEA InterPro2GO InterPro:IPR003602 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003916 DNA topoisomerase activity F IEA InterPro2GO InterPro:IPR005738 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003916 DNA topoisomerase activity F IEA InterPro2GO InterPro:IPR013497 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003916 DNA topoisomerase activity F IEA InterPro2GO InterPro:IPR013824 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003916 DNA topoisomerase activity F IEA InterPro2GO InterPro:IPR013825 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003916 DNA topoisomerase activity F IEA Swiss-Prot Keywords2GO SP_KW:KW-0799 83333 20101127 UniProtKB
UniProtKB P14294 topB GO:0003917 DNA topoisomerase type I activity F IDA PMID:6326814 83333 20100621 EcoliWiki
UniProtKB P14294 topB GO:0003917 DNA topoisomerase type I activity F IEA InterPro2GO InterPro:IPR000380 83333 20101127 InterPro
UniProtKB P14294 topB GO:0003917 DNA topoisomerase type I activity F IEA EC2GO EC:5.99.1.2 83333 20100703 UniProtKB
UniProtKB P14294 topB GO:0005515 protein binding F IPI PMID:15690043 frlR (FRLR_ECOLI) 83333 20101127 IntAct
UniProtKB P14294 topB GO:0005524 ATP binding F IEA Swiss-Prot Keywords2GO SP_KW:KW-0067 83333 20101127 UniProtKB
UniProtKB P14294 topB GO:0016853 isomerase activity F IEA Swiss-Prot Keywords2GO SP_KW:KW-0413 83333 20101127 UniProtKB
UniProtKB P14294 topB GO:0005694 chromosome C IEA InterPro2GO InterPro:IPR000380 83333 20101127 InterPro
UniProtKB P14294 topB GO:0005694 chromosome C IEA InterPro2GO InterPro:IPR003601 83333 20101127 InterPro
UniProtKB P14294 topB GO:0005694 chromosome C IEA InterPro2GO InterPro:IPR003602 83333 20101127 InterPro
UniProtKB P14294 topB GO:0005694 chromosome C IEA InterPro2GO InterPro:IPR005738 83333 20101127 InterPro
UniProtKB P14294 topB GO:0005694 chromosome C IEA InterPro2GO InterPro:IPR013497 83333 20101127 InterPro
UniProtKB P14294 topB GO:0005694 chromosome C IEA InterPro2GO InterPro:IPR013824 83333 20101127 InterPro
UniProtKB P14294 topB GO:0005694 chromosome C IEA InterPro2GO InterPro:IPR013825 83333 20101127 InterPro

Copied from [1] Last updated Dec 2 2010

3D Structures of Topoisomerase

Updated on 26-September-2018

References

  1. ↑ Champoux JJ. DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem. 2001;70:369-413. PMID:11395412 doi:http://dx.doi.org/10.1146/annurev.biochem.70.1.369
  2. ↑ Slesarev AI, Stetter KO, Lake JA, Gellert M, Krah R, Kozyavkin SA. DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote. Nature. 1993 Aug 19;364(6439):735-7. PMID:8395022 doi:http://dx.doi.org/10.1038/364735a0
  3. ↑ Coss A, Tosetto M, Fox EJ, Sapetto-Rebow B, Gorman S, Kennedy BN, Lloyd AT, Hyland JM, O'Donoghue DP, Sheahan K, Leahy DT, Mulcahy HE, O'Sullivan JN. Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis. Cancer Lett. 2009 Apr 18;276(2):228-38. doi: 10.1016/j.canlet.2008.11.018. Epub, 2008 Dec 25. PMID:19111388 doi:http://dx.doi.org/10.1016/j.canlet.2008.11.018
  4. ↑ Tse-Dinh YC. Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases. Infect Disord Drug Targets. 2007 Mar;7(1):3-9. PMID:17346206


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