Ribosomal protein P0

Function

Ribosomal protein P0 (RPLP0) is one of the 3 phosphoproteins in the large 60S subunit of the eukaryotic ribosome. RPLP0 is a functional equivalent of E. coli RPL10 protein^[1]. RPLP0 monomer forms a pentamer with dimers of RPLP1 and RPLP2.

Relevance

RPLP0 may be one of the major target antigens of anti-endothelial cell antibodies in patients with mixed connective tissue disease^[2].

3D Structures of Ribosomal protein P0

Updated on 22-December-2019

• P0 in the 50S subunit

• • 3a1y – RPLP0 N-terminal + RPLP1 N-terminal – Pyrococcus horikoshii
    

• P0 in the 60S subunit

See Ribosome

• • 6j3l – RPLP0 N-terminal + RPLP1 residues 105-186 – silk moth - NMR
    

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References

1. ↑ Rodriguez-Mateos M, Garcia-Gomez JJ, Francisco-Velilla R, Remacha M, de la Cruz J, Ballesta JP. Role and dynamics of the ribosomal protein P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae. Nucleic Acids Res. 2009 Dec;37(22):7519-32. doi: 10.1093/nar/gkp806. Epub . PMID:19789271 doi:http://dx.doi.org/10.1093/nar/gkp806
2. ↑ Naniwa T, Sugiura Y, Banno S, Yoshinouchi T, Matsumoto Y, Ueda R. Ribosomal P protein P0 as a candidate for the target antigen of anti-endothelial cell antibodies in mixed connective tissue disease. Clin Exp Rheumatol. 2007 Jul-Aug;25(4):593-8. PMID:17888216