5z2q
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Vgll1-TEAD4 core complex== | |
| + | <StructureSection load='5z2q' size='340' side='right' caption='[[5z2q]], [[Resolution|resolution]] 2.74Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5z2q]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4eaz 4eaz]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z2Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z2q OCA], [http://pdbe.org/5z2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z2q RCSB], [http://www.ebi.ac.uk/pdbsum/5z2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z2q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. [[http://www.uniprot.org/uniprot/VGLL1_MOUSE VGLL1_MOUSE]] May act as a specific coactivator for the mammalian TEFs (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is determined in this study. Remarkably, Vgll1 interacts with TEAD in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5, a proliferation-promoting gene, and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ, Vgll1 has the potential to promote cancer progression. | ||
| - | + | Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.,Pobbati AV, Chan SW, Lee I, Song H, Hong W Structure. 2012 Jul 3;20(7):1135-40. Epub 2012 May 24. PMID:22632831<ref>PMID:22632831</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5z2q" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Pobbati, A V]] | ||
[[Category: Song, H]] | [[Category: Song, H]] | ||
| - | [[Category: | + | [[Category: Co-regulator]] |
| + | [[Category: Tead]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
| + | [[Category: Vestigial]] | ||
| + | [[Category: Vgll1]] | ||
Revision as of 05:46, 31 January 2018
Vgll1-TEAD4 core complex
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Categories: Pobbati, A V | Song, H | Co-regulator | Tead | Transcription | Transcription factor | Vestigial | Vgll1
