6c12
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==SDHA-SDHE complex== | |
| - | + | <StructureSection load='6c12' size='340' side='right' caption='[[6c12]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c12]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C12 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate_dehydrogenase_(quinone) Succinate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.1 1.3.5.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c12 OCA], [http://pdbe.org/6c12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c12 RCSB], [http://www.ebi.ac.uk/pdbsum/6c12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c12 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SDHA_ECO57 SDHA_ECO57]] Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.[UniProtKB:P0AC41] [[http://www.uniprot.org/uniprot/SDHE_ECO57 SDHE_ECO57]] An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.[UniProtKB:G4V4G2] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Maher, M J]] | ||
| + | [[Category: Assembly factor]] | ||
| + | [[Category: Oxidoreductase-chaperon complex]] | ||
| + | [[Category: Succinate dehydrogenase]] | ||
Revision as of 05:07, 8 March 2018
SDHA-SDHE complex
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